Metal complexes synthesis and properties Open access Peer reviewed

Exploring the Anticancer Potential of Schiff Base Complexes: A Mini‐Review

Atif Ahmad, Anam, Marcos V. Palmeira‐Mello, Sabir Khan and 1 more

ChemMedChem | Sep 9, 2026

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This mini‐review provides a comprehensive overview of Schiff base complexes reported over the last 5 years, highlighting the recent advances related to their biological investigations.

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Schiff bases are well known for their ability to form stable coordination compounds with several transition metals, making them valuable for medicinal chemistry purposes. These metal-based compounds have attracted significant attention due to their enhanced biological activities, particularly their ability to act toward anticancer chemotherapy. This mini-review provides a comprehensive overview of Schiff base complexes reported over the last 5 years, highlighting the recent advances related to their biological investigations. Cytotoxicity and interactions with biological targets have been detailed. The mechanisms underlying the capacity of these complexes to induce cell death in cancer cells are also described.

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Atif Ahmad

first | Universidade Estadual Paulista (Unesp)

Anam

middle | Universidade Estadual Paulista (Unesp) | ORCID 0009-0006-3792-1163

Marcos V. Palmeira‐Mello

middle | Universidade Federal de São Carlos | ORCID 0000-0003-2550-5315

Sabir Khan

middle | Universidade Federal de Pelotas | ORCID 0000-0003-4557-238X

José Clayston Melo Pereira

last | Universidade Estadual Paulista (Unesp) | ORCID 0000-0002-1647-5575

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@article{Ahmad2026Exploring,
  title = {Exploring the Anticancer Potential of Schiff Base Complexes: A Mini‐Review},
  author = {Atif Ahmad and Anam and Marcos V. Palmeira‐Mello and Sabir Khan and José Clayston Melo Pereira},
  journal = {ChemMedChem},
  year = {2026},
  doi = {10.1002/cmdc.70484},
  url = {https://doi.org/10.1002/cmdc.70484}
}

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