Catalytic C–H Functionalization Methods
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Abstract
Abstract
C(sp2)−C(sp3) bond-forming reactions, which can increase the Fsp3 carbons, have emerged as a valuable approach for drug discovery. Herein, we report on the cobalt(III)-catalyzed chemoselective C(sp2)−H alkylation using bifunctional alkylzinc reagents as alkylation agents. The mild nucleophilic nature of organozinc reagents and the mild reaction conditions translated into a broad functional group tolerance and thus enabled the late-stage functionalization of highly functionalized drug molecules. In addition, the use of an earth-abundant cobalt catalyst and low-toxic zinc reagents highlighted an environmentally benign system.
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@article{Oyama2026Versatile,
title = {Versatile Cobalt(III)-Catalyzed Chemoselective C−H Alkylation with Polyfunctional Alkylzinc Reagents},
author = {Tsuyoshi Oyama and Stig D. Friis and Elisa Lai and Magnus J. Johansson and Prof. Dr. Lutz Ackermann},
journal = {ACS Catalysis},
year = {2026},
doi = {10.1021/acscatal.6c02833},
url = {https://doi.org/10.1021/acscatal.6c02833}
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