Genetic factors in colorectal cancer
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Abstract
Abstract
AIM: to evaluate the risk of recurrent intussusception after removal of hamartomas in patients with Peutz-Jeghers syndrome (PJS) and to analyze the safety of endoscopic removal of small bowel hamartomatous polyps in this patient population. P ATIENT S AND METHODS: single-center retrospective study evaluated the endoscopic management of confirmed PJS followed from January 2022 to December 2025 in 39 patients. There were 103 elective procedures: 1) balloonassisted enteroscopy (BAE) with polypectomy (n = 92), and 2) intraoperative enteroscopy (IOE) (n = 11). The primary endpoint was the recurrent intussusception confirmed by imaging. Time-to-event analysis was performed using the Nelson-Aalen method. RESULT S: a total of 686 small bowel hamartomatous polyps were removed. The median number of polyps removed per procedure was 5 (IQR 3–8) for BAE and 10 (IQR 8–17) for IOE. Median operation time was 90 (58–115) minutes for BAE and 300 (200–360) minutes for IOE. Complications occurred in 11/103 (10.7%) cases: 7/92 (7.6%) with BAE and 4/11 (36.3%) with IOE. Most complications were managed endoscopically — 5/7 (71.5%) in the BAE group and 1/4 (25.0%) in the IOE group. An active endoscopic strategy using BAE enabled organ-sparing treatment of intussusception in 13 out of 15 (86.7%) cases. The cumulative probability of recurrent intussusception within the first year of follow-up was 20.4% (95% CI 0,0–43.9), and the median time to event was 23.9 months. CONCLUSIONS: balloon-assisted enteroscopy as a minimally invasive approach demonstrates high efficacy in resolving intussusception. Despite treatment, a significant risk of recurrent intussusception persists, necessitating longterm follow-up. BAE shows an acceptable safety profile, whereas IOE is associated with a higher complication rate, reflecting its use in complex cases.
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@article{Abdulzhalieva2026Endoscopic,
title = {Endoscopic removal of small bowel polyps in patients with Peutz-Jeghers syndrome},
author = {E. U. Abdulzhalieva and А. А. Ликутов and T. A. Savelyeva and D. Yu. Pikunov and T. A. Vlasko and M. A. Ignatenko},
journal = {Koloproktologia},
year = {2026},
doi = {10.33878/2073-7556-2026-25-3-12-22},
url = {https://doi.org/10.33878/2073-7556-2026-25-3-12-22}
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