Syphilis Diagnosis and Treatment Peer reviewed

Biett's Sign: A Diagnostic Clue to Secondary Syphilis

Ramamoorthy Logamoorthy, Natarajan Kannan Aswin, Kaliaperumal Karthikeyan

British Journal of Dermatology | Jul 7, 2026

Abstract

Abstract

A 36-year-old otherwise healthy male with a history of multiple recent sexual partners presented with annular erythematous plaques on the lower legs and hyperpigmented palmoplantar macules with a peripheral collarette of scales suggestive of Biett's sign. Secondary syphilis was confirmed by a VDRL titer of 1:8 and reactive TPHA. This case highlights the diagnostic value of recognizing Biett's sign, as a characteristic clue to secondary syphilis.

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Authors

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Ramamoorthy Logamoorthy

first | Sri Manakula Vinayagar Medical College and Hospital

Natarajan Kannan Aswin

middle | Sri Manakula Vinayagar Medical College and Hospital

Kaliaperumal Karthikeyan

last | Sri Manakula Vinayagar Medical College and Hospital

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Citation

BibTeX

@article{Logamoorthy2026Biett,
  title = {Biett's Sign: A Diagnostic Clue to Secondary Syphilis},
  author = {Ramamoorthy Logamoorthy and Natarajan Kannan Aswin and Kaliaperumal Karthikeyan},
  journal = {British Journal of Dermatology},
  year = {2026},
  doi = {10.1093/bjd/ljag276},
  url = {https://doi.org/10.1093/bjd/ljag276}
}

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