Congenital Heart Disease Studies
Open access
Peer reviewed
Abstract
Abstract
Objective Congenital heart disease is the most common birth defect and carries a high risk of seizures; however, specific risk factors and long-term neurodevelopmental outcomes remain poorly defined. We aimed to identify factors associated with seizure occurrence and evaluate neurodevelopmental outcomes in children with congenital heart disease. Methods This prospective cohort study included 31,734 singleton live births in Lanzhou, China (2018–2023) followed for 18 months. Maternal, demographic, and clinical data were prospectively collected. Congenital heart disease phenotypes were classified as left-to-right shunt, cyanotic, left-sided, or single-ventricle lesions. Univariate logistic regression was conducted to identify factors associated with clinical seizures, and electroclinical and neurodevelopmental profiles were systematically evaluated. Results Congenital heart disease was diagnosed in 392 infants (1.2%), of whom 23 (5.9%) experienced clinical seizures. Lower birthweight, prolonged hospitalization, and extracorporeal membrane oxygenation support were significantly associated with seizure occurrence (all P < 0.001). Among congenital heart disease phenotypes, single-ventricle physiology had the highest seizure incidence (5.8%, P < 0.001). Electroencephalography identified focal impaired awareness seizures ( n = 13), electrographic-only seizures ( n = 2), and diverse interictal abnormalities. At 18 months, children with seizures demonstrated significantly lower motor scores ( P = 0.038) and higher rates of global developmental delay/intellectual disability ( P < 0.001). Conclusions Seizures represent a critical complication in infants with congenital heart disease, particularly those with single-ventricle physiology or requiring prolonged hospitalization or mechanical circulatory support. Seizure development was associated with poorer 18-month neurodevelopmental outcomes, underscoring the need for proactive neurological surveillance and larger multicenter studies to identify independent risk pathways.
Direct answer
What can I do from this paper page?
Use this page to scan "Seizures in congenital heart disease: risks, outcomes, and birth cohort data from China" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Congenital Heart Disease Studies research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Wang2026Seizures,
title = {Seizures in congenital heart disease: risks, outcomes, and birth cohort data from China},
author = {Li Wang and Lei Cao and Chuan Zhang and Wei Zhang},
journal = {Frontiers in Pediatrics},
year = {2026},
doi = {10.3389/fped.2026.1936201},
url = {https://doi.org/10.3389/fped.2026.1936201}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Congenital Heart Disease Studies research papers?
Follow Congenital Heart Disease Studies research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Seizures in congenital heart disease: risks, outcomes, and birth cohort data from China. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app