Chromatin Remodeling and Cancer
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Abstract
Abstract
ABSTRACT Malignant rhabdoid tumor of the kidney (MRTK) is a rare, highly aggressive renal neoplasm predominantly affecting infants, carrying a poor prognosis. We report a 7-month-old female who presented with a 10-day history of painless gross hematuria. Abdominal imaging revealed a large heterogeneous left renal mass without vascular invasion or distant metastases. Left radical nephrectomy with regional lymphadenectomy achieved complete resection (COG Local Stage II, node-negative). Immunohistochemistry demonstrated complete loss of INI1 expression, and next-generation sequencing confirmed a pathogenic SMARCB1 deletion. This case highlights the diagnostic and therapeutic challenges of MRTK in infancy and highlights the indispensable role of molecular confirmation.
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@article{AlQahtani2026Malignant,
title = {Malignant rhabdoid tumor of the kidney in a 7-month-old infant: A rare case report with molecular confirmation of SMARCB1 deletion},
author = {MoathA AlQahtani and Ahmed A. Alzuwayyid and Salem A. Bahdilh and Abdelazim Abasher and Omaya Banihani},
journal = {Urology Case Reports},
year = {2026},
doi = {10.1016/j.eucr.2026.103599},
url = {https://doi.org/10.1016/j.eucr.2026.103599}
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