Ionic liquids properties and applications
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The reported ILRSs 5 and 4 showed good antioxidant and anticancer activities and may be used as future anticancer drugs.
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Aims To develop effective functional ionic-liquid-related salts (ILRSs) as future anticancer drugs.Materials and Methods Twelve imidazole-based ionic-liquid-related salts were synthesized and characterized by spectroscopic methods. These ILRSs were used to study the antioxidant and anticancer activities, DNA titration, modeling, and in-silico studies.Results Among 12 ILRSs, ILRSs 5 and 4 indicated superior activities, showing higher scavenging percentages (70.7% and 65.5%) and lower IC50 values than the standard ascorbic acid. ILRSs 5 and 4 showed the most effective activities with MCF-7 cells, with viability values of 52.17% and 53.67% at 10 µM and IC50 values of 10.87 and 11.03 µM, respectively. DNA-binding studies showed moderate to strong interactions with Ct-DNA (binding constants: 104 to 105 M−1). The modeling studies of compounds A and B with DNA confirmed one hydrogen bond with −8.7 and −8.2 kcal/mol binding affinities.Conclusions The reported ILRSs 5 and 4 showed good antioxidant and anticancer activities and may be used as future anticancer drugs.
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@article{Ali2026From,
title = {From design to functionality of ionic-liquid-related salts: DNA titration, antioxidants, and anticancer activities},
author = {Salim Ali and Ming‐Fa Hsieh and Zheng‐Yuan Su and Mouslim Messali and Noureddine El Messaoudi and Shilpi Khurana and Imran Ali},
journal = {Future Medicinal Chemistry},
year = {2026},
doi = {10.1080/17568919.2026.2714030},
url = {https://doi.org/10.1080/17568919.2026.2714030}
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