Genomics and Phylogenetic Studies Open access Peer reviewed

The UCSC Genome Browser database: 2026 update

Jonathan D. Casper, Matthew L Speir, Brian J. Raney, Gerardo Perez and 17 more

Nucleic Acids Research | Nov 18, 2025 | 31 citations

Abstract

Abstract

Now in its 25th year of operation, the UCSC Genome Browser (https://genome.ucsc.edu) provides a central location for researchers around the world to display and compare annotations on assembled genomes. Highlighted updates include a positional heatmap display, used to show data on functional consequences of mutation from MaveDB; QuickLift, a tool to copy annotation data seen on one assembly for display on another related assembly; and HubSpace, an initiative to simplify the process of creating and using track hubs by providing each user account with dedicated storage on UCSC's infrastructure.

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Authors

Researchers on this paper

Jonathan D. Casper

first | University of California, Santa Cruz | ORCID 0009-0009-5722-1916

Matthew L Speir

middle | University of California, Santa Cruz | ORCID 0000-0002-2035-1129

Brian J. Raney

middle | University of California, Santa Cruz | ORCID 0000-0002-9708-1390

Gerardo Perez

middle | University of California, Santa Cruz | ORCID 0009-0004-7658-2219

Luis R Nassar

middle | University of California, Santa Cruz | ORCID 0000-0002-6706-2586

Christopher M. Lee

middle | University of California, Santa Cruz | ORCID 0000-0001-6574-3567

Angie S. Hinrichs

middle | University of California, Santa Cruz | ORCID 0000-0002-1697-1130

Jairo Navarro Gonzalez

middle | University of California, Santa Cruz | ORCID 0000-0003-4022-4829

Clay Fischer

middle | University of California, Santa Cruz

Mark Diekhans

middle | University of California, Santa Cruz | ORCID 0000-0002-0430-0989

Hiram Clawson

middle | University of California, Santa Cruz | ORCID 0000-0002-0480-0545

Anna Benet‐Pagès

middle | Helmholtz Zentrum München | ORCID 0000-0001-6770-1299

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Citation

BibTeX

@article{Casper2025UCSC,
  title = {The UCSC Genome Browser database: 2026 update},
  author = {Jonathan D. Casper and Matthew L Speir and Brian J. Raney and Gerardo Perez and Luis R Nassar and Christopher M. Lee and Angie S. Hinrichs and Jairo Navarro Gonzalez and Clay Fischer and Mark Diekhans and Hiram Clawson and Anna Benet‐Pagès and Galt P Barber and Charles Vaske and Marijke J. van Baren and Y. Rodríguez and Jaidan Ashlyn Jenkins-Kiefer and Megna Chalamala and David Haussler and William Kent and Maximilian Haeussler},
  journal = {Nucleic Acids Research},
  year = {2025},
  doi = {10.1093/nar/gkaf1250},
  url = {https://doi.org/10.1093/nar/gkaf1250}
}

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