Lipoproteins and Cardiovascular Health Peer reviewed

Evolocumab in Patients without a Previous Myocardial Infarction or Stroke

Erin A. Bohula, Nicholas A. Marston, Ajay Bhatia, Gaetano Maria De Ferrari and 18 more

New England Journal of Medicine | Nov 8, 2025 | 42 citations

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What this paper is about

PCSK9 inhibition with evolocumab led to a lower risk of first cardiovascular events than placebo among patients with atherosclerosis or diabetes and without a previous myocardial infarction or stroke.

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PCSK9 inhibition with evolocumab led to a lower risk of first cardiovascular events than placebo among patients with atherosclerosis or diabetes and without a previous myocardial infarction or stroke. (Funded by Amgen; VESALIUS-CV ClinicalTrials.gov number, NCT03872401.).

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Authors

Researchers on this paper

Erin A. Bohula

first | Thrombolysis in Myocardial Infarction Study Group | ORCID 0000-0002-5559-8172

Nicholas A. Marston

middle | Thrombolysis in Myocardial Infarction Study Group | ORCID 0000-0001-6164-4617

Ajay Bhatia

middle | Amgen (United States)

Gaetano Maria De Ferrari

middle | Azienda Ospedaliera Citta' della Salute e della Scienza di Torino | ORCID 0000-0003-4940-0876

Lawrence A. Leiter

middle | St. Michael's Hospital | ORCID 0000-0002-1040-6229

José Carlos Nicolau

middle | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo | ORCID 0000-0002-9680-3689

Jeong-Gun Park

middle | Thrombolysis in Myocardial Infarction Study Group

Julia Kuder

middle | Thrombolysis in Myocardial Infarction Study Group | ORCID 0000-0002-7099-1538

Sabina A. Murphy

middle | Thrombolysis in Myocardial Infarction Study Group | ORCID 0000-0002-8231-3611

Huei Wang

middle | Amgen (United States) | ORCID 0000-0002-9903-1979

V. Bláha

middle | University Hospital Hradec Králové | ORCID 0000-0001-8088-9919

Andrzej Budaj

middle | Grochowski Hospital

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Citation

BibTeX

@article{Bohula2025Evolocumab,
  title = {Evolocumab in Patients without a Previous Myocardial Infarction or Stroke},
  author = {Erin A. Bohula and Nicholas A. Marston and Ajay Bhatia and Gaetano Maria De Ferrari and Lawrence A. Leiter and José Carlos Nicolau and Jeong-Gun Park and Julia Kuder and Sabina A. Murphy and Huei Wang and V. Bláha and Andrzej Budaj and Jan H. Cornel and Assen Goudev and Róbert Gábor Kiss and Alberto Lorenzatti and Alexander Parkhomenko and Marcoli Cyrille and Gabriel Paiva da Silva Lima and E. Magnus Ohman and Robert P. Giugliano and Marc S. Sabatine},
  journal = {New England Journal of Medicine},
  year = {2025},
  doi = {10.1056/nejmoa2514428},
  url = {https://doi.org/10.1056/nejmoa2514428}
}

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