RNA regulation and disease
Open access
Peer reviewed
Scollr summary
What this paper is about
New insights are provided into TE transcription in the PD brain and it is suggested that TEs may contribute to neuroinflammation and pathological progression in PD.
Full abstract
Read the full abstract
Parkinson's disease (PD) is a neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TEs) have been linked to inflammation, but their potential role in PD remains unexplored. Using bulk- and single-nuclei RNA-seq of postmortem brain tissue from four brain regions, we studied TE transcription and its correlation with PD neuroinflammation. Over a thousand TEs, including LINE-1 s and ERVs, were expressed in a cell type- and region-specific manner in the human brain. Increased TE expression was found in microglia and neurons in the substantia nigra and putamen of PD brains, but not amygdala or prefrontal cortex, compared to controls. This TE activation correlated with an innate immune response in the same brain regions. The link between an interferon response and TE activation was mechanistically confirmed using human pluripotent stem cell-derived microglia and neurons. Our findings provide insights into TE transcription in the PD brain and suggest that TEs may contribute to neuroinflammation and pathological progression in PD.
Direct answer
What can I do from this paper page?
Use this page to scan "Activation of transposable elements is linked to a region- and cell type–specific interferon response in Parkinson’s disease" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow RNA regulation and disease research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Garza2026Activation,
title = {Activation of transposable elements is linked to a region- and cell type–specific interferon response in Parkinson’s disease},
author = {Raquel Garza and Anita Adami and Arun Thiruvalluvan and Sasvi S. Wijesinghe and Annabel J. Curle and Oliver H. Tam and Talitha Forcier and Danai A Lagka and Nina-Lydia Kazakou and Diahann A. M. Atacho and Yogita Sharma and Vivien Horváth and Sara Bermudez and Jenny Johansson and Daniel B. Rainbow and Laura Castilla‐Vallmanya and Joanne Jones and Annelies Quaegebeur and Molly Hammell and Agnete Kirkeby and Roger A. Barker and Johan Jakobsson},
journal = {Science Advances},
year = {2026},
doi = {10.1126/sciadv.aed2952},
url = {https://doi.org/10.1126/sciadv.aed2952}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new RNA regulation and disease research papers?
Follow RNA regulation and disease research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Activation of transposable elements is linked to a region- and cell type–specific interferon response in Parkinson’s disease. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app