Cancer Mechanisms and Therapy
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A virus-induced BmTSN-BmSREBP1 axis that links host lipid metabolism to BmCPV replication is revealed and provides new insights into virus-host interactions in insects.
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Bombyx mori cytoplasmic polyhedrosis virus (BmCPV), a double-stranded RNA reovirus, causes significant losses in sericulture; however, the host factors that support its replication remain poorly understood. Here, we identify Tudor staphylococcal nuclease (TSN) as a critical pro-viral host factor in silkworms. TSN is a multifunctional, evolutionarily conserved protein involved in transcription and RNA processing. BmTSN expression was increased markedly in BmCPV-infected midgut tissues. RNAi-mediated knockdown in BmN cells suppresses viral replication, whereas overexpression enhances it. Mechanistically, BmTSN drives a metabolic shift by enhancing lipid accumulation; knockdown of BmTSN reduces the expression of BmSREBP1 and other lipid-regulatory genes. Disruption of either BmTSN or BmSREBP1 reduces BmCPV replication. In a reciprocal effect, RNAi-mediated knockdown of BmSREBP1 also reduces BmTSN expression. Furthermore, BmSREBP1 transcriptionally activates BmTSN expression by binding to the BmTSN promoter, suggesting a regulatory loop between these factors. Together, these findings reveal a virus-induced BmTSN-BmSREBP1 axis that links host lipid metabolism to BmCPV replication. This work identifies BmTSN as a key host-dependency factor and provides new insights into virus-host interactions in insects.
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@article{Awais2026Tudor,
title = {Tudor staphylococcal nuclease promotes Bombyx mori cytoplasmic polyhedrosis virus replication through lipid metabolic reprogramming in silkworms},
author = {Mian Muhammad Awais and Nasir Mehmood and Wensheng Yu and Ayman Asif and Y. Zhang and Jingchen Sun and Huichao Yan},
journal = {Insect Science},
year = {2026},
doi = {10.1111/1744-7917.70344},
url = {https://doi.org/10.1111/1744-7917.70344}
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