Head and Neck Surgical Oncology
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A case of a giant oncocytic sinonasal papilloma treated by endoscopic surgery is reported, highlighting the diagnostic approach and comparing the findings with the existing literature.
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Sinonasal papilloma is a rare benign neoplasm arising from the Schneiderian epithelium lining the nasal cavity and paranasal sinuses. It is classified into three histological subtypes: exophytic, inverted, and oncocytic, the latter being the least common. We report a case of a giant oncocytic sinonasal papilloma treated by endoscopic surgery, highlighting the diagnostic approach and comparing the findings with the existing literature. Histopathological examination confirmed the diagnosis. Immunohistochemical analysis demonstrated p53 positivity in both the cytoplasm and nucleus, and Ki-67 showed a low labeling index. The patient underwent complete excision via an endoscopic approach. Notably, the lesion was larger than those typically described in the literature. An 18-month follow-up revealed no complications or evidence of recurrence. It is important to bear in mind that a combined tomographic and histopathological evaluation is essential for accurate diagnosis and therapeutic approach.
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@article{Corra2026Giant,
title = {Giant Oncocytic Sinonasal Papilloma: A Rare Case},
author = {André Gustavo da Silva Corrêa and Adriane Xavier de Morais and Lucio Murilo dos Santos and Carlos Castilho Borges and Ana Lia Anbinder and Renata Falchete do Prado},
journal = {Diagnostics},
year = {2026},
doi = {10.3390/diagnostics16162632},
url = {https://doi.org/10.3390/diagnostics16162632}
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