Congenital heart defects research
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Strikingly, dexamethasone or ibuprofen substantially restored regeneration in Junb deficient zebrafish larvae, demonstrating that hyperinflammation is a major determinant of regenerative failure.
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Abstract Inflammation is essential for regeneration yet can also drive fibroinflammatory remodeling; what determines these opposing outcomes remains unclear. Comparative transcriptomic analyses revealed that injured mouse hearts activated a broad inflammatory program, whereas zebrafish hearts mounted a restricted response characterized by selective il11 induction. This divergence extended across tissues and species: the non-regenerative mammalian injuries examined shared an inflammatory signature distinct from regenerative vertebrate contexts. We identified the AP-1 transcription factor Junb as an Il-11–Stat3-dependent regulator that restrains inflammation during fin fold regeneration. Combined loss of junba and junbb amplified a mammalian-like inflammatory program, increased neutrophil recruitment and fibroinflammatory gene expression, and reduced proliferation and regenerative outgrowth. Strikingly, dexamethasone or ibuprofen substantially restored regeneration in Junb deficient zebrafish larvae, demonstrating that hyperinflammation is a major determinant of regenerative failure. Thus, the Il-11–Stat3–Junb axis maintains a regeneration permissive inflammatory state preventing a regenerative response from shifting toward mammalian-like fibroinflammation.
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@article{Ishaque2026Junb,
title = {Junb acts downstream of the Il-11/Stat3 signaling axis to limit tissue damage induced fibro-inflammation during regeneration},
author = {Julia Ishaque and Eric Bienert and Amrutha Manikandan and Srinivas Allanki and Laia Cañes Esteve and Jochen Poeling and Stefan Guenther and Didier Y. R. Stainier and Samuel Sossalla and Arica Beisaw and Sven Reischauer},
journal = {bioRxiv (Cold Spring Harbor Laboratory)},
year = {2026},
doi = {10.64898/2026.08.04.742722},
url = {https://doi.org/10.64898/2026.08.04.742722}
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