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Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes

Stephen J. Nicholls, Imre Pávó, Deepak L. Bhatt, John B. Buse and 23 more

New England Journal of Medicine | Dec 17, 2025 | 44 citations

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What this paper is about

Among patients with type 2 diabetes and atherosclerotic cardiovascular disease, tirzepatide was noninferior to dulaglutide with respect to a composite of death from cardiovascular causes, myocardial infarction, or stroke.

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Among patients with type 2 diabetes and atherosclerotic cardiovascular disease, tirzepatide was noninferior to dulaglutide with respect to a composite of death from cardiovascular causes, myocardial infarction, or stroke. (Funded by Eli Lilly; SURPASS-CVOT ClinicalTrials.gov number, NCT04255433.).

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Authors

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Stephen J. Nicholls

first | Monash University | ORCID 0000-0002-9668-4368

Imre Pávó

middle | Eli Lilly (United States) | ORCID 0000-0002-2016-7049

Deepak L. Bhatt

middle | Mount Sinai Hospital | ORCID 0000-0002-1278-6245

John B. Buse

middle | University of North Carolina at Chapel Hill | ORCID 0000-0002-9723-3876

Stefano Del Prato

middle | Scuola Superiore Sant'Anna | ORCID 0000-0002-5388-0270

Steven E. Kahn

middle | VA Puget Sound Health Care System | ORCID 0000-0001-7307-9002

A. Michael Lincoff

middle | Cleveland Clinic Lerner College of Medicine | ORCID 0000-0001-8175-2121

Darren K. McGuire

middle | Parkland Health & Hospital System | ORCID 0000-0002-6412-7989

Debra L. Miller

middle | Eli Lilly (United States) | ORCID 0000-0002-8544-174X

Michael A. Nauck

middle | Universitätsmedizin Greifswald | ORCID 0000-0002-5749-6954

Hiroshi Nishiyama

middle | Eli Lilly (United States) | ORCID 0000-0001-5034-5777

Steven E. Nissen

middle | Cleveland Clinic | ORCID 0000-0002-7231-6464

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BibTeX

@article{Nicholls2025Cardiovascular,
  title = {Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes},
  author = {Stephen J. Nicholls and Imre Pávó and Deepak L. Bhatt and John B. Buse and Stefano Del Prato and Steven E. Kahn and A. Michael Lincoff and Darren K. McGuire and Debra L. Miller and Michael A. Nauck and Hiroshi Nishiyama and Steven E. Nissen and Naveed Sattar and Govinda Weerakkody and Russell J. Wiese and Bernard Zinman and Sophia Zoungas and Jan Basile and Melanie J Davies and Francesco Giorgino and Monika Kellerer and Linong Ji and Tamás Várkonyi and Venu Menon and Jonathan Broder and Alan Herschtal and David A. D’Alessio},
  journal = {New England Journal of Medicine},
  year = {2025},
  doi = {10.1056/nejmoa2505928},
  url = {https://doi.org/10.1056/nejmoa2505928}
}

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