Hippo pathway signaling and YAP/TAZ
Open access
Peer reviewed
Scollr summary
What this paper is about
Kaiso is established as a novel TAZ interaction partner and HIF1A-AS3 is identified as a shared downstream target of TAZ and Kaiso, suggesting a potential profibrotic regulatory network that promotes HSC activation and may represent a therapeutic target for liver fibrosis.
Full abstract
Read the full abstract
Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are key regulators of hepatic stellate cell (HSC) activation and liver fibrosis. While the canonical YAP/TAZ-TEAD axis is well-characterized, non-canonical interaction partners and downstream long non-coding RNAs (lncRNAs) that orchestrate fibrogenic programs in HSCs remain undefined. Using BioID and next-generation sequencing (NGS) in LX-2 cells, we identified YAP/TAZ-interactomes and YAP/TAZ-regulated lncRNAs. BioID results and proximity ligation assay (PLA) identified the transcription factor Kaiso as a TAZ interaction partner. Functionally, Kaiso knockdown suppressed key aspects of HSC activation in LX-2 cells. We next integrated our NGS results from YAP/TAZ-knockdown in LX-2 cells with publicly available Kaiso ChIP-seq data. This identified HIF1A-AS3 as a common downstream lncRNA. ChIP-qPCR confirmed direct binding of Kaiso to the HIF1A-AS3 promoter. Furthermore, HIF1A-AS3 silencing mirrored the functional effects of Kaiso knockdown. Global proteomic profiling following knockdown of TAZ, Kaiso, or HIF1A-AS3 revealed a network of commonly regulated proteins enriched for pathways central to HSC activation. In conclusion, we establish Kaiso as a novel TAZ interaction partner and identify HIF1A-AS3 as a shared downstream target of TAZ and Kaiso, suggesting a potential profibrotic regulatory network that promotes HSC activation and may represent a therapeutic target for liver fibrosis.
Direct answer
What can I do from this paper page?
Use this page to scan "Kaiso Is a Novel TAZ-Interaction Partner That Promotes Hepatic Stellate Cell Activation and Regulates the Downstream lncRNA HIF1A-AS3" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Hippo pathway signaling and YAP/TAZ research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Abdelhamid2026Kaiso,
title = {Kaiso Is a Novel TAZ-Interaction Partner That Promotes Hepatic Stellate Cell Activation and Regulates the Downstream lncRNA HIF1A-AS3},
author = {Amira Khaled Abdelhamid and Fabiola Pedrini and Jennifer Schmitt and Ibrahim Hassan Fayed and Aya Osama and Hannah H. Rashwan and Diana M. F. Hanna and Esther T. Menze and Sameh Magdeldin and Marcin Luzarowski and Carsten Sticht and Ebtehal El-Demerdash and Kai Breuhahn and Ahmed Ihab Abdelaziz and Nada El‐Ekiaby},
journal = {International Journal of Molecular Sciences},
year = {2026},
doi = {10.3390/ijms27177847},
url = {https://doi.org/10.3390/ijms27177847}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Hippo pathway signaling and YAP/TAZ research papers?
Follow Hippo pathway signaling and YAP/TAZ research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Kaiso Is a Novel TAZ-Interaction Partner That Promotes Hepatic Stellate Cell Activation and Regulates the Downstream lncRNA HIF1A-AS3. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app