Virus-based gene therapy research
Open access
Peer reviewed
Abstract
Abstract
Abstract Although adeno-associated virus (AAV) has enjoyed enormous success as a delivery modality for gene therapy, it suffers from high prevalence of preexisting neutralizing antibodies in human populations, limiting who can receive potentially life-saving treatments. As a novel solution to this issue, we employed SpyTag-SpyCatcher molecular glue technology to facilitate packaging of AAVs inside of recombinant protein vault nanoparticles. Vaults are endogenous particles produced by mammalian cells. We therefore hypothesized that they may shield packaged molecules from neutralizing antibodies. Vaults have previously been utilized to deliver drugs and proteins into cells, but our study represents the first time anyone has packaged an entire virus inside of a vault. We showed that our vaultAAV delivery vehicle transduces cells in the presence of anti-AAV neutralizing serum. VaultAAV is positioned as a new gene therapy delivery platform with potential to overcome the neutralizing antibody problem, expanding the scope of AAV treatments.
Direct answer
What can I do from this paper page?
Use this page to scan "Encapsulation of AAVs into Protein Vault Nanoparticles as a Novel Solution to Gene Therapy’s Neutralizing Antibody Problem" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Virus-based gene therapy research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Collins2026Encapsulation,
title = {Encapsulation of AAVs into Protein Vault Nanoparticles as a Novel Solution to Gene Therapy’s Neutralizing Antibody Problem},
author = {Logan Thrasher Collins and Wandy L. Beatty and Buhle Moyo and Michele Alves‐Bezerra and Ayrea Hurley and Qing Lou and Z. Hong Zhou and William R. Lagor and Gang Bao and Selvarangan Ponnazhagan and Randall McNally and Leonard H. Rome and David T. Curiel},
journal = {ACS Synthetic Biology},
year = {2026},
doi = {10.1021/acssynbio.6c00512},
url = {https://doi.org/10.1021/acssynbio.6c00512}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Virus-based gene therapy research papers?
Follow Virus-based gene therapy research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Encapsulation of AAVs into Protein Vault Nanoparticles as a Novel Solution to Gene Therapy’s Neutralizing Antibody Problem. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app