Cardiac Valve Diseases and Treatments
Peer reviewed
Scollr summary
What this paper is about
The findings support the implementation of tailored surveillance and preventive strategies to mitigate BVF-related risk and support the implementation of tailored surveillance and preventive strategies to mitigate BVF-related risk.
Full abstract
Read the full abstract
BACKGROUND: Data on the long-term incidence and clinical impact of bioprosthetic valve failure (BVF) after transcatheter aortic valve replacement remain limited. This study aimed to assess the incidence, predictors, and clinical impact of BVF following transcatheter aortic valve replacement. METHODS: We analyzed data from an international, multicenter registry including consecutive patients undergoing transcatheter aortic valve replacement at 13 centers. The primary outcome was BVF according to Valve Academic Research Consortium-3 criteria. The cumulative incidence of BVF was estimated using a competing-risk approach. The association between BVF and clinical outcomes was assessed using competing-risk models with BVF as a time-dependent covariate. RESULTS: Among 7501 patients, BVF occurred in 380 (5.1%) patients over a median follow-up of 4 (interquartile range, 2–5) years. The cumulative incidence of BVF increased over time, reaching 1.4% at 1 year, 4.6% at 5 years, and 8.3% at 10 years. Independent predictors of BVF included younger age, smoking, balloon-expandable valve, prosthesis size <26 mm, valve-in-valve procedure, mean gradient at discharge ≥15 mm Hg, moderate or severe aortic regurgitation at discharge, and early hemodynamic valve deterioration. BVF was independently associated with an increased risk of all-cause mortality (adjusted hazard ratio, 1.72 [95% CI, 1.47–2.01]; P <0.001), cardiovascular mortality (adjusted hazard ratio, 3.23 [95% CI, 2.73–3.82]; P <0.001), stroke (adjusted hazard ratio, 2.08 [95% CI, 1.02–4.23]; P =0.043), and heart failure hospitalization (adjusted hazard ratio, 1.43 [95% CI, 1.03–1.98]; P =0.032). Consistent findings were observed in different sensitivity analyses. CONCLUSIONS: BVF is a clinically relevant event associated with adverse long-term outcomes. These findings support the implementation of tailored surveillance and preventive strategies to mitigate BVF-related risk.
Direct answer
What can I do from this paper page?
Use this page to scan "Bioprosthetic Valve Failure After Transcatheter Aortic Valve Replacement" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Cardiac Valve Diseases and Treatments research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Trimaille2026Bioprosthetic,
title = {Bioprosthetic Valve Failure After Transcatheter Aortic Valve Replacement},
author = {Antonin Trimaille and Pedro Cepas‐Guillén and Marina Ureña and Alberto Alperi and Gabriela Veiga Fernández and Luis Nombela‐Franco and Victòria Vilalta and María Del Trigo and Antonio J. Muñoz-García and Giovanni Esposito and Vincent Auffret and David del Val and Vicenç Serra and Jorge Nuche and Lluís Asmarats and Ander Regueiro and Adrien Carmona and Quentin Fischer and Pablo Avanzas and Víctor Fradejas-Sastre and Ivan Sanchez and Michele Trichilo and J. Domínguez and Anna Franzone and Maxime Nolf and Fernándo Alfonso and Pedro Diaz Pockels and Rocío Rodríguez-Santolino and Dabit Arzamendi and Eduardo Flores‐Umanzor and Olivier Morel and Marisa Avvedimento and Josep Rodés‐Cabau},
journal = {Circulation Cardiovascular Interventions},
year = {2026},
doi = {10.1161/circinterventions.126.016892},
url = {https://doi.org/10.1161/circinterventions.126.016892}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Cardiac Valve Diseases and Treatments research papers?
Follow Cardiac Valve Diseases and Treatments research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Bioprosthetic Valve Failure After Transcatheter Aortic Valve Replacement. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app