Ovarian function and disorders
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Peer reviewed
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The proposed pathophysiology of PCOS from a translational perspective is discussed from a translational perspective, and the existing diagnostic criteria of PCOS and current management strategies are reviewed.
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Polycystic ovary syndrome (PCOS), also known as polyendocrine metabolic ovarian syndrome (PMOS), is the most common endocrinologic disorder to affect women. Despite this, the pathophysiology of the disease is not entirely known. This has hindered the diagnosis of the disease and appropriate treatment for millions of individuals. In this Review, we discuss the proposed pathophysiology of PCOS from a translational perspective. We review the existing diagnostic criteria of PCOS and current management strategies. Finally, we discuss the long-term health sequelae associated with PCOS, future directions, and areas of needed research in this often-overlooked disease.
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@article{Chan2026Polyendocrine,
title = {Polyendocrine metabolic ovarian syndrome (PMOS)/polycystic ovary syndrome (PCOS): current and future trends},
author = {Jessica L. Chan and Irene Masini and Margareta D. Pisarska},
journal = {Journal of Clinical Investigation},
year = {2026},
doi = {10.1172/jci202824},
url = {https://doi.org/10.1172/jci202824}
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