Hemoglobinopathies and Related Disorders
Peer reviewed
Scollr summary
What this paper is about
HU may exert therapeutic benefit not only by increasing HbF but also through anti-inflammatory and antioxidant effects, leading to improved hematological stability and fewer complications in SCD.
Full abstract
Read the full abstract
BACKGROUND AND OBJECTIVES: Sickle cell disease (SCD) is characterized by chronic hemolysis, inflammation, oxidative stress, and recurrent vaso-occlusive complications leading to significant morbidity. Hydroxyurea (HU), a widely used disease-modifying therapy, increases fetal hemoglobin (HbF) and reduces clinical complications. Emerging evidence suggests additional anti-inflammatory and antioxidant effects. The objectives of this study were to compare the inflammatory markers, oxidative stress markers, hematological parameters, and quality of life from baseline to 6 months after HU therapy among patients with SCD. MATERIALS AND METHODS: In this prospective observational study, 16 HU-naïve patients with SCD were evaluated at baseline and after 6 months of HU therapy. Investigations included inflammatory markers (interleukin-6 [IL-6] and tumor necrosis factor-alpha [TNF-α]), oxidative stress markers (malondialdehyde [MDA] and glutathione [GSH]), hematological parameters (HbF, sickle hemoglobin [HbS], leukocyte count, and neutrophil-to-lymphocyte ratio [NLR]), and quality of life assessed using the 36-Item Short Form Health Survey questionnaire. RESULTS: Significant reductions in inflammatory markers were observed, with TNF-α decreasing from 5.82 ± 2.82 pg/mL to 4.64 ± 2.65 pg/mL (P = 0.006) and median IL-6 levels decreasing from 6.32 to 4.42 pg/mL (P = 0.001). Oxidative stress improved, with reduced MDA levels (P = 0.011) and increased GSH levels (P = 0.001). Hematological parameters showed significant improvement, including increased HbF and reductions in HbS, leukocyte count, and NLR (P < 0.001). HU therapy was well tolerated, with good compliance, improved quality of life, and a low incidence of complications. CONCLUSION: HU may exert therapeutic benefit not only by increasing HbF but also through anti-inflammatory and antioxidant effects, leading to improved hematological stability and fewer complications in SCD.
Direct answer
What can I do from this paper page?
Use this page to scan "Evaluation of hydroxyurea effect in patients with sickle cell disease: A prospective observational study" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Hemoglobinopathies and Related Disorders research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Battina2026Evaluation,
title = {Evaluation of hydroxyurea effect in patients with sickle cell disease: A prospective observational study},
author = {Anusha Battina and Snehalata Gajbhiye and Chaitali Chindhalore and Ganesh N. Dakhale and Apurva Bhoyar and Amol Dube and Sunita Kumbhalkar and Vishvdeep Khushoo and Richa Juneja},
journal = {Indian Journal of Pharmacology},
year = {2026},
doi = {10.4103/ijp.ijp_270_26},
url = {https://doi.org/10.4103/ijp.ijp_270_26}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Hemoglobinopathies and Related Disorders research papers?
Follow Hemoglobinopathies and Related Disorders research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Evaluation of hydroxyurea effect in patients with sickle cell disease: A prospective observational study. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app