Cervical Cancer and HPV Research Peer reviewed

Noninferiority of One HPV Vaccine Dose to Two Doses

Aimée R. Kreimer, Carolina Porras, Danping Liu, Allan Hildesheim and 22 more

New England Journal of Medicine | Dec 3, 2025 | 25 citations

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One dose of either a bivalent or nonavalent HPV vaccine provided protection against HPV16 or HPV18 infection and was not inferior to two doses.

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One dose of either a bivalent or nonavalent HPV vaccine provided protection against HPV16 or HPV18 infection and was not inferior to two doses. (Funded by the National Cancer Institute and others; ESCUDDO ClinicalTrials.gov number, NCT03180034.).

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Authors

Researchers on this paper

Aimée R. Kreimer

first | National Cancer Institute | ORCID 0000-0002-6073-2591

Carolina Porras

middle | Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud | ORCID 0000-0002-4592-3883

Danping Liu

middle | National Cancer Institute | ORCID 0000-0001-5483-6303

Allan Hildesheim

middle | National Cancer Institute | ORCID 0000-0003-0257-2363

Loretto J Carvajal

middle | Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud | ORCID 0000-0002-4965-7615

Rebeca Ocampo

middle | Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud | ORCID 0000-0002-8069-5142

Byron Romero

middle | Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud

Mitchell H. Gail

middle | National Cancer Institute | ORCID 0000-0002-3919-3263

Bernal Cortés

middle | Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud

Mónica S. Sierra

middle | National Cancer Institute | ORCID 0000-0003-1286-057X

Karla Coronado

middle | Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud

Joshua N. Sampson

middle | National Cancer Institute | ORCID 0000-0003-2875-3365

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Citation

BibTeX

@article{Kreimer2025Noninferiority,
  title = {Noninferiority of One HPV Vaccine Dose to Two Doses},
  author = {Aimée R. Kreimer and Carolina Porras and Danping Liu and Allan Hildesheim and Loretto J Carvajal and Rebeca Ocampo and Byron Romero and Mitchell H. Gail and Bernal Cortés and Mónica S. Sierra and Karla Coronado and Joshua N. Sampson and Casey Dagnall and Daniela Mora and Troy J. Kemp and Michael Zúñiga and Lígia A. Pinto and Gloriana Barrientos and John Schussler and Yenory Estrada and Carlos Ávila and Jean Cyr and Stephen J. Chanock and Douglas R. Lowy and John T. Schiller and Rolando Herrero},
  journal = {New England Journal of Medicine},
  year = {2025},
  doi = {10.1056/nejmoa2506765},
  url = {https://doi.org/10.1056/nejmoa2506765}
}

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