Immunotherapy and Immune Responses
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Understanding how CD8+ T cell fates are determined will enable the rational design of immunotherapies that can modulate DC-T cell interactions to generate beneficial CD8+ T cell fates.
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Immune responses against cancer are dominated by T cell exhaustion and dysfunction. Recent advances have underscored the critical role of early priming interactions in establishing T cell fates. In this review, we explore the importance of dendritic cell (DC) signals in specifying CD8+ T cell fates in cancer, drawing on insights from acute and chronic viral infection models. We highlight the role of DCs in lymph nodes and tumors in maintaining stem-like CD8+ T cells, which are critical for durable antitumor immune responses. Understanding how CD8+ T cell fates are determined will enable the rational design of immunotherapies, particularly therapeutic cancer vaccines, that can modulate DC-T cell interactions to generate beneficial CD8+ T cell fates.
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@article{Bhandarkar2025Architects,
title = {Architects of immunity: How dendritic cells shape CD8 + T cell fate in cancer},
author = {Vidit Bhandarkar and Teresa Dinter and Stefani Spranger},
journal = {Science Immunology},
year = {2025},
doi = {10.1126/sciimmunol.adf4726},
url = {https://doi.org/10.1126/sciimmunol.adf4726}
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