Cardiac Imaging and Diagnostics
Open access
Peer reviewed
Scollr summary
What this paper is about
Among patients undergoing CCTA, CAD was more frequent and severe in those with diabetes, and the risk of CVD or MI increased with CAD severity, approximately doubling in each category when diabetes was present.
Full abstract
Read the full abstract
BACKGROUND: This study aimed to assess the relationship between coronary CT angiography detected coronary artery disease (CAD) and long-term cardiovascular outcomes among individuals with and without diabetes mellitus (DM). METHODS: A retrospective cohort study of patients undergoing CCTA at two medical centers between 2006 and 2024. Patients with prior CAD, advanced kidney disease, or malignancy were excluded. DM was defined by diagnostic codes or elevated hemoglobin A1c. CCTA findings were categorized as no CAD, nonobstructive CAD (1-49% stenosis), or obstructive CAD (≥ 50% stenosis). The primary outcome was a composite of cardiovascular death (CVD) or myocardial infarction (MI). RESULTS: Among 22,377 patients (median age 56 [IQR 47-65]; 45% women), 3,245 (14.5%) had diabetes. Individuals with diabetes were older and had more cardiovascular risk factors. Obstructive CAD was more frequent in patients with diabetes (33% vs. 19%), whereas no CAD was less common (23% vs. 42%). Over a median follow-up of 6 years (IQR 3.9-9.5), the primary outcome occurred more than twice as often among those with diabetes (7.8% vs. 3.1%; P < 0.001). Event rates increased with CAD severity and remained higher among individuals with diabetes across all categories. After adjustment, obstructive CAD remained significantly associated with the primary outcome in both groups (DM: HR 2.9 [95% CI 1.8-4.6], P < 0.001; non-DM: HR 2.7 [95% CI 2.1-3.4]), p < 0.001). CONCLUSIONS: Among patients undergoing CCTA, CAD was more frequent and severe in those with diabetes, and the risk of CVD or MI increased with CAD severity, approximately doubling in each category when diabetes was present.
Direct answer
What can I do from this paper page?
Use this page to scan "Prognostic Value of Coronary CT Angiography Among Patients With and Without Diabetes: The Mass General Brigham CCTA registry" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Cardiac Imaging and Diagnostics research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Shiyovich2026Prognostic,
title = {Prognostic Value of Coronary CT Angiography Among Patients With and Without Diabetes: The Mass General Brigham CCTA registry},
author = {Arthur Shiyovich and Daniel Huck and Rhanderson Cardoso and Adam N. Berman and Stephanie A. Besser and David Biery and Milena Petranović and Brittany N. Weber and Jon Hainer and Camila V. Blair and Nandini M. Meyersohn and Avinainder Singh and Vinit Baliyan and Michael T. Lu and Michael Steigner and Ayaz Aghayev and Khurram Nasir and Christopher P. Cannon and Sandeep Hedgire and Marcelo Di Carli and Brian Ghoshhajra and Ron Blankstein},
journal = {Cardiovascular Diabetology},
year = {2026},
doi = {10.1186/s12933-026-03193-1},
url = {https://doi.org/10.1186/s12933-026-03193-1}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Cardiac Imaging and Diagnostics research papers?
Follow Cardiac Imaging and Diagnostics research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Prognostic Value of Coronary CT Angiography Among Patients With and Without Diabetes: The Mass General Brigham CCTA registry. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app