Systemic Sclerosis and Related Diseases
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Growing evidence suggests an association between specific autoantibody profiles and distinct capillaroscopic patterns, indicating a link between immunological mechanisms and microvascular damage.
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Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease with multifaceted clinical manifestations, unclear etiology, and specific immunological phenomena that continue to be a challenge for modern science regarding their etiopathogenetic role in the onset and course of the disease. In SSc, different autoantibodies could be detected, and three are defined as diagnostic. They are considered potential biomarkers as they may eventually be used to distinguish distinct patient groups with specific clinical manifestations. Three specific autoantibodies and capillaroscopic abnormalities were included in the 2013 ACR/EULAR classification criteria for SSc. The autoantibodies defined as diagnostic in SSc are anti-centromere, anti-topoisomerase I, and anti-RNA polymerase III antibodies. Other SSc-associated antibodies are anti-Th/To, Ku, PDGFR, PM-Scl, etc. Growing evidence suggests an association between specific autoantibody profiles and distinct capillaroscopic patterns, indicating a link between immunological mechanisms and microvascular damage.
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@article{Dzhambazova2026ssociation,
title = {Аssociation of Capillaroscopic Findings with Autoantibodies in Systemic Sclerosis},
author = {Sanie Dzhambazova and Sevdalina Lambova},
journal = {Rheumatology (Bulgaria)},
year = {2026},
doi = {10.35465/d297b958},
url = {https://doi.org/10.35465/d297b958}
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