Metal complexes synthesis and properties
Peer reviewed
Scollr summary
What this paper is about
Three thiosemicarbazone ligands were synthesized from para‐nitrobenzaldehyde and substituted thiosemicarbazides and converted to their corresponding iron(III)–bipyridine complexes, displaying promising multi‐target activity warranting further mechanistic and preclinical study.
Full abstract
Read the full abstract
ABSTRACT Schiff base ligands and their transition metal complexes continue to attract attention for their versatile coordination behavior and biological relevance. Herein, three thiosemicarbazone ligands (L1–L3) were synthesized from para‐nitrobenzaldehyde and substituted thiosemicarbazides and converted to their corresponding iron(III)–bipyridine complexes (FT1–FT3). The compounds were characterized by FT–IR, UV–vis, 1 H/ 1 3 C NMR, ESI–MS, EPR, molar conductivity, and elemental analysis. Spectroscopic data confirmed coordination through the azomethine nitrogen and thione sulfur, evidenced by shifts in characteristic bands and new Fe─N and Fe─S vibrations. DFT optimization revealed a distorted octahedral geometry and provided HOMO–LUMO gaps, global reactivity descriptors, and molecular electrostatic potential maps. Anticancer (SiHa), antimycobacterial, and antifungal assays showed that FT3 was the most active, giving 72.85% antifungal inhibition at 1000 ppm together with improved anticancer and antibacterial activity. Molecular docking against HPV‐18 E2 (PDB 1F9F) and CYP51 (PDB 1EA1) gave favorable binding energies that correlated with the experimental trends, FT3 forming the most stable interactions. ADME predictions indicated broadly acceptable, though preliminary, pharmacokinetic behavior. Overall, these iron(III) Schiff base complexes display promising multi‐target activity warranting further mechanistic and preclinical study.
Direct answer
What can I do from this paper page?
Use this page to scan "Design, Synthesis and Biological Profiling of Fe(III)–Bipyridine Schiff Base Complexes: Experimental, Computational and Pharmacokinetic Insights" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Metal complexes synthesis and properties research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Bano2026Design,
title = {Design, Synthesis and Biological Profiling of Fe(III)–Bipyridine Schiff Base Complexes: Experimental, Computational and Pharmacokinetic Insights},
author = {Swaila Bano and Saniya Firdaus and Sujeet Yadav and Farha Arshi and Saurabh Kumar and Monisha Banerjee and Harshita Gaurav and Amritesh C. Shukla and Anushka Bari and Sudheer Kumar Singh and Ashok K. Singh},
journal = {ChemistrySelect},
year = {2026},
doi = {10.1002/slct.74570},
url = {https://doi.org/10.1002/slct.74570}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Metal complexes synthesis and properties research papers?
Follow Metal complexes synthesis and properties research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Design, Synthesis and Biological Profiling of Fe(III)–Bipyridine Schiff Base Complexes: Experimental, Computational and Pharmacokinetic Insights. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app