Neurological disorders and treatments
Open access
Peer reviewed
Abstract
Abstract
Postoperative quality-of-life (QoL) outcomes after subthalamic deep brain stimulation in Parkinson's disease vary widely. Previous studies based on PDQ-39 summary scores have reported opposing relationships between baseline and postoperative QoL, reflecting analytic variability, measurement noise, and limited feature scope. To address these inconsistencies, we analyzed 130 patients using an explainable random-forest classifier with SHAP analysis trained to predict QoL changes exceeding minimal clinically important difference thresholds. Baseline variables included PDQ-39 subscores, along with demographic, motor, cognitive, and affective measures, and electrode coordinates derived from imaging. Predictors of QoL improvement included younger age, greater preoperative disease-related emotional burden, and electrode placement at the motor-associative transition in the right subthalamic nucleus. The model achieved an area under the curve of 0.70 on the held-out test set, with balanced sensitivity and specificity. Identifying interpretable cut-offs for age, emotional burden and electrode location supports individualized counseling and treatment planning, advancing outcome prediction in neuromodulation.
Direct answer
What can I do from this paper page?
Use this page to scan "Age, emotional burden and deep brain stimulation electrode location shape Parkinson’s disease quality of life" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Neurological disorders and treatments research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Khoshnoud2026emotional,
title = {Age, emotional burden and deep brain stimulation electrode location shape Parkinson’s disease quality of life},
author = {Shiva Khoshnoud and Farzin Negahbani and Idil Cebi and D Weiss and Alireza Gharabaghi},
journal = {npj Digital Medicine},
year = {2026},
doi = {10.1038/s41746-026-02828-7},
url = {https://doi.org/10.1038/s41746-026-02828-7}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Neurological disorders and treatments research papers?
Follow Neurological disorders and treatments research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Age, emotional burden and deep brain stimulation electrode location shape Parkinson’s disease quality of life. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app