Parkinson's Disease Mechanisms and Treatments
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Abstract
Abstract
Drug induced Parkinsonism is a common and potentially reversible adverse effect associated with dopamine receptor blocking agents, particularly antipsychotics. Elderly patients are at higher risk due to age related neurodegenerative changes and polypharmacy. This report presents a 63 year old female with a history of type 2 diabetes Mellitus, systemic hypertension, hypothyroidism and psychiatric illness, who developed Parkinsonism features during treatment with risperidone. She presented with fatigue, reduced oral intake and progressive difficulty in walking. Neurological evaluation and imaging studies supported the diagnosis of drug induced parkinsonism. MRI brain revealed generalized neuroparenchymal atrophy with hypertensive microangiopathic changes and small vessel ischemic disease. MRI spine showed multilevel degenerative disc changes. A multidisciplinary approach was adopted in the management of the patient including the modification of Psychiatric medications, discontinuation of the potential contributing agents and the initiation of supportive measures. The patient showed improvement following these interventions. The case highlights the importance of early identification of extrapyramidal symptoms and careful use of antipsychotics in elderly patients with multiple risk factors.
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@article{Dharan32026Case,
title = {A Case Report on Risperidone Induced Parkinsonism},
author = {Anchana A. T.1, Grace N. Raju*2, Shaiju S. Dharan3},
journal = {International Journal of Medical & Pharmaceutical Sciences},
year = {2026},
doi = {10.5281/zenodo.22016681},
url = {https://doi.org/10.5281/zenodo.22016681}
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