Adipokines, Inflammation, and Metabolic Diseases
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This study revealed a significant association among resistin, apolipoproteins, and OxLDL in the pro-atherogenic state associated with obesity, and their potential as a composite panel for enhanced cardiovascular risk stratification in obese and hypertensive male patients is suggested.
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Obesity and hypertension are critical risk factors for cardiovascular disease (CVD). Adipose tissue dysfunction in obesity promotes a pro-inflammatory, pro-atherogenic state via altered adipokine secretion (e.g., resistin), dyslipidemia, and increased oxidized low-density lipoprotein (OxLDL).To investigate the correlation between serum resistin, Apolipoprotein A1 (ApoA1), Apolipoprotein B100 (ApoB100), and oxidized low-density lipoprotein (OxLDL) with body mass index (BMI) and lipid profiles in healthy, obese, hypertensive, and obese hypertensive males.In this cross-sectional comparative study of 60 males, serum resistin, ApoA1, ApoB100, and OxLDL were quantified by ELISA. Lipid profiles were determined using standard enzymatic methods. Relationships between biomarkers, BMI, and lipid parameters were assessed using Pearson's correlation with Bonferroni correction applied for multiple comparisons.BMI was positively correlated with OxLDL (r=0.507, p<0.001) and negatively correlated with ApoA1 (r=-0.403, p=0.001). Resistin was positively correlated with total cholesterol, triglycerides, LDL, and VLDL and negatively correlated with HDL. ApoB100 and OxLDL were positively correlated with atherogenic lipids, whereas ApoA1 was negatively correlated.This study revealed a significant association among resistin, apolipoproteins, and OxLDL in the pro-atherogenic state associated with obesity. The strong correlations between these biomarkers and dyslipidemia suggest their potential as a composite panel for enhanced cardiovascular risk stratification in obese and hypertensive male patients. However, as this study was restricted to male participants, the generalizability of these findings to females requires further investigation.
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@article{scollr2026Estimation,
title = {Estimation of Apolipoproteins with OxLDL in Male Patients with Hypertension.},
journal = {Al-Furat Journal for Health and Medical Sciences},
year = {2026},
doi = {10.46649/qy4ay262},
url = {https://doi.org/10.46649/qy4ay262}
}FAQ
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