Photodynamic Therapy Research Studies
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3-PtTPyP and 3-PdTPyP are promising photosensitizers for the inactivation of MDR Gram-positive bacteria associated with canine otitis externa, and the performance against the MDR Gram-positive bacteria was dependent of species.
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The increasing prevalence of multidrug-resistant (MDR) bacteria isolated from dogs with external otitis presents a major therapeutic challenge in veterinary medicine, and antimicrobial photodynamic therapy has emerged as a promising alternative. Meso-tetra-pyridyl porphyrins bearing peripheral platinum(II) (3-PtTPyP) and palladium(II) (3-PdTPyP) complexes have shown activity against clinically relevant Gram-positive bacteria and may represent effective photosensitizers for otitis-associated MDR pathogens. Therefore, this study evaluated the antimicrobial activity and effects on bacterial morphology and adhesive properties of 3-PtTPyP and 3-PdTPyP on MDR isolates of Corynebacterium auriscanis, Enterococcus faecalis, Staphylococcus epidermidis, and Streptococcus canis obtained from dogs with otitis. Antibacterial activity was investigated by determining the minimum inhibitory and bactericidal concentrations (MBC) and by bacterial time-kill assay under white-light irradiation for 120 min. Alterations in bacterial morphology and nanomechanical properties were investigated using atomic force microscopy (AFM). Both porphyrins promoted a marked reduction in bacterial concentrations under white-light irradiation using MBC, although their bactericidal effects varied depending on the bacterial species and porphyrin. The 3-PtTPyP exhibited a more consistent photodynamic response against E. faecalis e C. auricanis, whereas 3-PdTPyP displayed greater effected against S. canis e S. epidermidis. AFM revealed pronounced changes in surface topography and nanomechanical properties after treatment with both porphyrins. Overall, these results demonstrate that 3-PtTPyP and 3-PdTPyP are promising photosensitizers for the inactivation of MDR Gram-positive bacteria associated with canine otitis externa, and the performance against the MDR Gram-positive bacteria was dependent of species.
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@article{Voigt2026Photoinactivation,
title = {Photoinactivation of multidrug-resistant Gram-positive bacteria isolated from dogs with otitis using tetra-cationic porphyrins bearing peripheral platinum(II) (3-PtTPyP) and palladium(II) (3-PdTPyP) complexes},
author = {Tauana Fernanda Jantsch Voigt and Eduarda Martins and Junior Navarini and Matheus Gass Lopes and Paulo R. Souza and Bernardo A. Iglesias and Fernanda Silveira Flôres Vogel and Letícia Trevisan Gressler and Juliana Felipetto Cargnelutti},
journal = {Current Microbiology},
year = {2026},
doi = {10.1007/s00284-026-05202-8},
url = {https://doi.org/10.1007/s00284-026-05202-8}
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