Ion Channels and Receptors
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The results suggest that A. hypogaea extract may contribute to the maintenance and improvement of the epidermal barrier function and the physicochemical properties of the components responsible for TRPV4 activation are examined.
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ABSTRACT Transient receptor potential vanilloid 4 (TRPV4) is a Ca 2+ -permeable non-selective cation channel and its activating stimuli include anandamide, bisandrographolide, citric acid, arachidonic acid metabolic products by epoxygenases, hypo-osmotic cell swelling, and warm temperature. TRPV4 is involved in Ca 2+ -dependent signal transduction in several tissues. Since the activation of TRPV4 facilitates adherens junction formation in the skin epithelium, compounds that activate TRPV4 are expected to maintain or improve the barrier function of epidermal cells. In this study, we found that the extract of Arachis hypogaea ( A. hypogaea ) activate human TRPV4 (hTRPV4). In the Ca 2+ -imaging experiment, the application of A. hypogaea extract exhibited an increase in intracellular Ca 2+ concentration ([Ca 2+ ] i ) in HEK293T cells expressing hTRPV4. The [Ca 2+ ] i increases by application of A. hypogaea extract were not observed in HEK293T cells expressing hTRPV1, mouse TRPV2, hTRPV3, hTRPM8, or hTRPA1. We then examined the physicochemical properties of the components responsible for TRPV4 activation. Ethanol extracts of A. hypogaea caused an increase in [Ca 2+ ] i in hTRPV4-expressing HEK293JN cells, whereas water, chloroform, and hexane extracts showed no activity. Moreover, the application of A. hypogaea extract enhanced transepithelial electrical resistance in the keratinocyte monolayer. These results suggest that A. hypogaea extract may contribute to the maintenance and improvement of the epidermal barrier function.
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@article{Akiyama2026Effects,
title = {Effects of Arachis hypogaea extract on TRPV4 activation and epidermal barrier function},
author = {Miyu Akiyama and Sayaka Takagi and Aya Yoshikoshi and Mari Iwase and Chihiro Honda and Tomoki Sato and Makoto Tominaga and Hisayoshi Hayashi and Shinji Miura and Shigenori Kumazawa and Kunitoshi Uchida},
journal = {bioRxiv (Cold Spring Harbor Laboratory)},
year = {2026},
doi = {10.64898/2026.08.17.745342},
url = {https://doi.org/10.64898/2026.08.17.745342}
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