Neurological disorders and treatments
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This work exposes physiological principles that enable real-time decoding of ongoing locomotor activities across motor fluctuations from the neural dynamics of the subthalamic nucleus and provides a blueprint for next-generation neuromodulation therapies that continuously select parameters optimized to the behavioral context and fluctuating physiology of each patient.
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Parkinson's disease leads to a spectrum of locomotor deficits that vary in severity with the nature of daily activities and the fluctuating physiology of patients. Many of these deficits remain inadequately addressed by existing deep brain stimulation therapies that rely on activity-agnostic parameters optimized for cardinal motor symptoms. By contrast, therapies embedding activity-specific parameters have the potential to better address the entire range of symptoms. Here we expose physiological principles that enable real-time decoding of ongoing locomotor activities across motor fluctuations from the neural dynamics of the subthalamic nucleus. This decoding steered activity-dependent adaptations of deep brain stimulation therapies that improved locomotor deficits while preserving efficacy for cardinal motor symptoms across activities of daily living. Our activity-dependent framework provides a blueprint for next-generation neuromodulation therapies that continuously select parameters optimized to the behavioral context and fluctuating physiology of each patient. ClinicalTrials.gov registration NCT06791902 .
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@article{Scafa2026Activity,
title = {Activity-dependent adaptive deep brain stimulation improves gait in Parkinson’s disease},
author = {Stefano Scafa and Valeria de Seta and Ruijia Wang and Paula Sánchez López and Andrea Sánchez López and Camille Varescon and Icare Sakr and Nadia Bérard and Lea Bole-Feysot and Celine Deschenaux and Ian Enderli and Yohann Thenaisie and Morgane Burri and Frédéric Merlos and Vanessa Fleury and Benoît Wicki and Ettore Accolla and Andria Tziakouri and Cécile Hubsch and Mayté Castro Jiménez and Julien F. Bally and Alessandro Puiatti and Kyuhwa Lee and Henri Lorach and Antoine Collomb‐Clerc and Jocelyne Bloch and Eduardo Martin Moraud},
journal = {Nature Medicine},
year = {2026},
doi = {10.1038/s41591-026-04432-4},
url = {https://doi.org/10.1038/s41591-026-04432-4}
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