Cardiac Structural Anomalies and Repair
Open access
Peer reviewed
Scollr summary
What this paper is about
Aeson TAH implantation appears to be a feasible bridge-to-transplant strategy for selected patients with irreparable post-myocardial infarction VSD that provided hemodynamic stabilization, facilitated recovery of end-organ function, and resulted in favorable short- to mid-term outcomes in an otherwise fatal clinical condition.
Full abstract
Read the full abstract
BACKGROUND: Post-myocardial infarction ventricular septal defect (VSD) is a rare but highly lethal complication of acute myocardial infarction. In cases of extensive septal destruction, surgical reconstruction is often not feasible. We report the first clinical experience with implantation of the Aeson total artificial heart (TAH) in patients with irreparable post-infarction VSD. METHODS: This multicenter retrospective analysis included 10 male patients with severe cardiogenic shock who underwent Aeson TAH implantation at four centers in Germany and France between November 2022 and March 2025. All patients required temporary mechanical circulatory support before implantation. Previous surgical VSD repair had failed in four patients, while six were considered unsuitable for surgical reconstruction because of extensive basal septal defects involving the atrioventricular valve apparatus. RESULTS: Following TAH implantation, early extubation was achieved in most patients, whereas three required temporary veno-venous extracorporeal membrane oxygenation support. No cases of permanent renal failure, irreversible hepatic dysfunction, or neurological complications such as stroke were observed. Eight patients (80%) were successfully bridged to heart transplantation after a median support duration of 167 days, while one patient remains on ongoing device support. During a median follow-up of 351 days (interquartile range, 202-470 days), four patients died. Overall survival was 80% at 6 months and 60% at 1 year after implantation. CONCLUSIONS: Aeson TAH implantation appears to be a feasible bridge-to-transplant strategy for selected patients with irreparable post-myocardial infarction VSD. The procedure provided hemodynamic stabilization, facilitated recovery of end-organ function, and resulted in favorable short- to mid-term outcomes in an otherwise fatal clinical condition.
Direct answer
What can I do from this paper page?
Use this page to scan "Initial Experience With the Aeson Total Artificial Heart in Patients With Ventricular Septal Defect After Acute Myocardial Infarction" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Cardiac Structural Anomalies and Repair research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Nozdrzykowski2026Initial,
title = {Initial Experience With the Aeson Total Artificial Heart in Patients With Ventricular Septal Defect After Acute Myocardial Infarction},
author = {Michal Nozdrzykowski and Olivier Bouchot and André Vincentelli and Bernd Panholzer and Saëd Jazayeri and Mouhamed Djahoum Moussa and Christian Latrémouille and Assad Haneya and Michael A. Borger and Alexey Dashkevich},
journal = {Artificial Organs},
year = {2026},
doi = {10.1111/aor.70218},
url = {https://doi.org/10.1111/aor.70218}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Cardiac Structural Anomalies and Repair research papers?
Follow Cardiac Structural Anomalies and Repair research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Initial Experience With the Aeson Total Artificial Heart in Patients With Ventricular Septal Defect After Acute Myocardial Infarction. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app