Neonatal Respiratory Health Research
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This study deciphered the spatiotemporal trajectory and function of an atypical population of macrophages after lung injury and identified a previously unappreciated population of reparative lung macrophages that could be targeted therapeutically to treat lung damage.
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The lung is constantly exposed to airborne pathogens and particles that can cause alveolar damage. Hence, appropriate repair responses are essential for gas exchange and life. Here, we deciphered the spatiotemporal trajectory and function of an atypical population of macrophages after lung injury. Post-influenza A virus (IAV) infection, short-lived monocyte-derived Ly6G-expressing macrophages (Ly6G+ Macs) were recruited to the alveoli of lung perilesional areas. Ly6G+ Macs engulfed immune cells, exhibited a high metabolic potential, and clustered with alveolar type 2 epithelial cells (AT2s) in zones of active epithelial regeneration. Ly6G+ Macs were partially dependent on granulocyte-macrophage colony-stimulating factor and interleukin-4 receptor signaling and were essential for AT2-dependent alveolar regeneration. Similar macrophages were recruited in other models of injury and in the airspaces of lungs from patients with suspected pneumonia. This study identifies perilesional alveolar Ly6G+ Macs as a spatially restricted, short-lived macrophage subset promoting epithelial regeneration postinjury, thus representing an attractive therapeutic target for treating lung damage.
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@article{Ruscitti2024Recruited,
title = {Recruited atypical Ly6G + macrophages license alveolar regeneration after lung injury},
author = {Cecilia Ruscitti and Joan Abinet and Pauline Maréchal and Margot Meunier and Constance De meeûs and Domien Vanneste and Pierre Janssen and Mickaël Dourcy and Marc Thiry and Fabrice Bureau and Christoph Schneider and Bénédicte Machiels and Andrés Hidalgo and Florent Ginhoux and Benjamin G Dewals and Julien Guiot and Florence Schleich and Mutien‐Marie Garigliany and Akeila Bellahcène and Coraline Radermecker and Thomas Marichal},
journal = {Science Immunology},
year = {2024},
doi = {10.1126/sciimmunol.ado1227},
url = {https://doi.org/10.1126/sciimmunol.ado1227}
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