Lipid metabolism and disorders
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Abstract
Abstract
Editing of ANGPTL3 was associated with few adverse events and resulted in reductions from baseline in ANGPTL3 levels. (Funded by CRISPR Therapeutics; Australia New Zealand Clinical Trials Registry number, ACTRN12623000809639.).
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@article{Laffin2025Phase,
title = {Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3},
author = {Luke J Laffin and Stephen J. Nicholls and Russell Scott and Peter Clifton and John E. Baker and Ashish Sarraju and Shweta Singh and Qiuqing Wang and Kathy Wolski and Huansheng Xu and Jen Nielsen and Jason M. Duran and Steven E. Nissen},
journal = {New England Journal of Medicine},
year = {2025},
doi = {10.1056/nejmoa2511778},
url = {https://doi.org/10.1056/nejmoa2511778}
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