Neuropeptides and Animal Physiology
Open access
Peer reviewed
Scollr summary
What this paper is about
Bidirectional relationships between brain NOP receptors and ethanol self-administration are demonstrated and evidence of subtle sex differences in these interactions is provided.
Full abstract
Read the full abstract
ABSTRACT Drugs that interact with brain nociceptin/orphanin FQ (NOP) receptors can decrease ethanol consumption in preclinical models of alcohol use disorder (AUD). Studies using positron emission tomography (PET imaging) in humans with AUD reported lower levels of NOP receptors compared to controls. Here, uptake of the NOP receptor–selective PET radiotracer [ 11 C]NOP‐1A was measured in monkeys (six males, five females) when ethanol‐naïve and again after a 4‐month induction procedure plus 6 months of ethanol drinking (22 h/day, 5 days/week). Although there were no sex differences in brain uptake of [ 11 C]NOP‐1A before ethanol self‐administration, sex differences were observed in relationships between [ 11 C]NOP‐1A uptake and ethanol‐related measures. Baseline [ 11 C]NOP‐1A uptake in the orbitofrontal cortex in males and caudate nucleus in females predicted future ethanol intakes. Moreover, chronic ethanol self‐administration produced changes in [ 11 C]NOP‐1A uptake in AUD‐related brain areas. Increases in uptake were observed in the putamen of both sexes and in the nucleus accumbens and amygdala of males; females showed a decrease in the insula. Changes in [ 11 C]NOP‐1A uptake in the orbitofrontal cortex, putamen and hypothalamus of males and caudate nucleus of females were related to ethanol intake. These results demonstrate bidirectional relationships between brain NOP receptors and ethanol self‐administration and provide evidence of subtle sex differences in these interactions.
Direct answer
What can I do from this paper page?
Use this page to scan "Sex‐Specific Relationships Between Nociceptin/Orphanin FQ Peptide (NOP) Receptors and Alcohol Drinking: Longitudinal PET Studies in Cynomolgus Monkeys" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Neuropeptides and Animal Physiology research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Czoty2026Specific,
title = {Sex‐Specific Relationships Between Nociceptin/Orphanin FQ Peptide (NOP) Receptors and Alcohol Drinking: Longitudinal PET Studies in Cynomolgus Monkeys},
author = {Paul W. Czoty and Kiran Kumar Solingapuram Sai and Mack Miller and Michael D. Moore and Paul Josef Myburgh and Laura R. Grace and Joshua N. Prete and Phillip M. Epperly},
journal = {Basic & Clinical Pharmacology & Toxicology},
year = {2026},
doi = {10.1111/bcpt.70282},
url = {https://doi.org/10.1111/bcpt.70282}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Neuropeptides and Animal Physiology research papers?
Follow Neuropeptides and Animal Physiology research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Sex‐Specific Relationships Between Nociceptin/Orphanin FQ Peptide (NOP) Receptors and Alcohol Drinking: Longitudinal PET Studies in Cynomolgus Monkeys. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app