Retinoids in leukemia and cellular processes Open access Peer reviewed

Acute Promyelocytic Leukemia With PML‐RARA Rearrangement: Clinical and Morphologic Features

Chukwuka Elendu, Ayodeji D. Johnson, Ayi T. Debua

Clinical Case Reports | Oct 30, 2026

Abstract

Abstract

Recognition of the characteristic morphologic features of acute promyelocytic leukemia on peripheral blood smear should prompt immediate initiation of all-trans retinoic acid while awaiting confirmatory testing, as early intervention is critical to reducing hemorrhagic mortality and improving clinical outcomes.

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Researchers on this paper

Chukwuka Elendu

first | ORCID 0000-0002-0249-1865

Ayodeji D. Johnson

middle | Boston Medical Center | ORCID 0009-0003-4049-7672

Ayi T. Debua

last | University Of Calabar Teaching Hospital

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Citation

BibTeX

@article{Elendu2026Acute,
  title = {Acute Promyelocytic Leukemia With PML‐RARA Rearrangement: Clinical and Morphologic Features},
  author = {Chukwuka Elendu and Ayodeji D. Johnson and Ayi T. Debua},
  journal = {Clinical Case Reports},
  year = {2026},
  doi = {10.1002/ccr3.73830},
  url = {https://doi.org/10.1002/ccr3.73830}
}

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