Vitamin C and Antioxidants Research
Peer reviewed
Scollr summary
What this paper is about
Vitamin-loaded TNVs increased brain levels of vitamins E and C, enhanced antioxidant defense and cognitive abilities, and reduced acetylcholinesterase activity in dementia rats, and TNV-C and TNV-E protected against neuroinflammation and neuritic plaque formation.
Full abstract
Read the full abstract
AIM: Oxidative stress (OS) contributes to Alzheimer's disease (AD) pathology. Vitamins C and E target OS, but their efficacies are limited by poor intracellular delivery. Encapsulation in nanovesicles (NVs) may improve targeted delivery for AD treatment. METHODS: Forty-five rats were randomly assigned to nine groups (n = 5 per group): normal control, scopolamine control, vitamin C, vitamin E, vitamin C + E, turmeric NVs (TNV), TNV-C, TNV-E, and donepezil. Treatment was administered intraperitoneally (IP) for one week before induction of the AD-like model using daily IP administration of scopolamine and continued for two weeks. During this time, behavioral activities were conducted, and brain tissues were collected for analysis. RESULTS: Vitamins C and E showed encapsulation efficiencies of 12.36 ± 1.01% and 55.24 ± 5.82%, with loading capacities of 14.34 ± 1.37% and 40.70 ± 3.52, respectively. TNV-C and TNV-E increased brain levels of vitamins E and C, enhanced antioxidant defense and cognitive abilities, and reduced acetylcholinesterase activity in dementia rats. TNV-C and TNV-E also protected against neuroinflammation and neuritic plaque formation. Vitamin-loaded TNVs were more effective than free vitamins in improving antioxidant status and cognitive outcomes in AD rats. CONCLUSION: This study highlights the potential of vitamin-loaded NVs as therapeutics for AD.
Direct answer
What can I do from this paper page?
Use this page to scan "Turmeric nanovesicles loaded with vitamins C and E attenuate oxidative stress and improve cognitive outcomes in rats with memory deficits" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Vitamin C and Antioxidants Research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Jiyah2026Turmeric,
title = {Turmeric nanovesicles loaded with vitamins C and E attenuate oxidative stress and improve cognitive outcomes in rats with memory deficits},
author = {Amina Jiyah and Ibrahim Bulama and Andrew Onu and Abubakar Yaya Gimba and Abdullahi Y. Abbas and Yusuf Saidu and Lawal Suleiman Bilbis and Suleiman Alhaji Muhammad},
journal = {Therapeutic Delivery},
year = {2026},
doi = {10.1080/20415990.2026.2715894},
url = {https://doi.org/10.1080/20415990.2026.2715894}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Vitamin C and Antioxidants Research papers?
Follow Vitamin C and Antioxidants Research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Turmeric nanovesicles loaded with vitamins C and E attenuate oxidative stress and improve cognitive outcomes in rats with memory deficits. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app