Cell death mechanisms and regulation
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This activation-state imaging approach allows detection of early molecular events preceding structural damage and supports the use of [18F]1 as a potential pharmacodynamic biomarker for assessing RIPK1 pathway engagement and therapeutic modulation.
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as a potential pharmacodynamic biomarker for assessing RIPK1 pathway engagement and therapeutic modulation.
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@article{Park2026Imaging,
title = {PET Imaging of Phosphorylated RIPK1 Reveals Necroptosis Activation In Vivo},
author = {Sun Mi Park and Tae Sup Lee and Jieun Lee and Jiwon Yoon and Bom Sahn Kim and Byung Seok Moon},
journal = {Molecular Pharmaceutics},
year = {2026},
doi = {10.1021/acs.molpharmaceut.6c00579},
url = {https://doi.org/10.1021/acs.molpharmaceut.6c00579}
}FAQ
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