Global Maternal and Child Health
Open access
Peer reviewed
Scollr summary
What this paper is about
A deeper understanding of cisplatin resistance in ovarian cancer offers promising strategies to overcome cisplatin resistance, especially in ovarian clear cell carcinoma, and could pave the way for targeted therapies aimed at improving ovarian cancer outcomes.
Full abstract
Read the full abstract
Cisplatin resistance in ovarian cancer, particularly in ovarian clear cell carcinoma, involves intricate mechanisms related to oxidative stress, deoxyribonucleic acid repair, and cell cycle. Resistance in ovarian clear cell carcinoma is associated with genes, such as pyruvate dehydrogenase kinase-2 and hepatocyte nuclear factor 1 beta, which enhance glycolysis and reduce reactive oxygen species that would normally facilitate cisplatin-induced deoxyribonucleic acid damage. Additionally, nuclear factor erythroid 2-related factor-2 and superoxide dismutase-2 play pivotal roles in regulating reactive oxygen species levels, thereby safeguarding ovarian clear cell carcinoma cells from oxidative damage. The postsynaptic density protein 95/discs large/zona occludens-1 (PDZ)-binding motif-angiopoietin-like 4-nicotinamide adenine dinucleotide phosphate oxidase-2 axis plays a crucial role in modulating ferroptosis, presenting potential therapeutic targets. A deeper understanding of these mechanisms offers promising strategies to overcome cisplatin resistance, particularly in ovarian clear cell carcinoma. These insights could pave the way for targeted therapies aimed at improving ovarian cancer outcomes, especially for ovarian clear cell carcinoma subtypes. Key Words: Reactive oxygen species, Ovarian neoplasms, Drug resistance, Neoplasm.
Direct answer
What can I do from this paper page?
Use this page to scan "The role of reactive oxygen species metabolism-related genes in mediating cisplatin resistance in ovarian clear cell carcinoma" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Global Maternal and Child Health research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{scollr2026role,
title = {The role of reactive oxygen species metabolism-related genes in mediating cisplatin resistance in ovarian clear cell carcinoma},
journal = {Journal of the Pakistan Medical Association},
year = {2026},
doi = {10.47391/jpma.22024},
url = {https://doi.org/10.47391/jpma.22024}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Global Maternal and Child Health research papers?
Follow Global Maternal and Child Health research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for The role of reactive oxygen species metabolism-related genes in mediating cisplatin resistance in ovarian clear cell carcinoma. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app