Metal complexes synthesis and properties
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Abstract
Abstract
We report a new chelating pyridyl–imine ligand bearing a riboflavin-derived pendant group and its Pt(II) complexes 1 and 2, designed as cisplatin- and oxaliplatin-like derivatives. Both complexes reacted with DNA and a histone-derived peptide, with 1 showing markedly higher covalent reactivity. However, this trend was not reflected in biological activity. Complex 2 displayed micromolar antiproliferative effects and pronounced antibacterial activity, particularly against Bacillus subtilis, whereas 1 was inactive in the tested models. Cellular accumulation studies excluded enhanced Pt uptake as the origin of this difference. Fluorescence microscopy performed on Escherichia Coli and Bacillus subtilis indicated that 2 affects bacterial DNA and membrane potential, consistent with a dual antibacterial mechanism. Comparison with oxaliplatin and the free flavin ligands showed that both the Pt–oxalate fragment and the riboflavin-containing ligand are required for activity.
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@article{Moran2026Flavin,
title = {Pt(II)-Flavin Complexes As Anticancer And Antibacterial Agents},
author = {María Jesús Moran and Igor V. Esarev and Nitin Kumar and Laura Marretta and Leo Pontfort and Ana Cristina Carrasco and Beatrice Bernadette Mascitti and Alessio Terenzi and Luisa Ronga and Ingo Ott and Luca Salassa},
journal = {ChemRxiv},
year = {2026},
doi = {10.26434/chemrxiv.15009344/v1},
url = {https://doi.org/10.26434/chemrxiv.15009344/v1}
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