Cytokine Signaling Pathways and Interactions
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Intratumoral injection of recombinant murine IL-12 (r-mIL-12) significantly prolonged mouse survival and suppressed tumor growth in immunocompetent mice, suggesting that local administration of r-mIL-12 may serve as an effective therapeutic approach for OSCC with mandibular bone invasion.
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OBJECTIVE: Oral squamous cell carcinoma (OSCC) frequently invades the mandibular bone, leading to metastasis and poor prognosis. This study aimed to evaluate the therapeutic effects of locally administered interleukin-12 (IL-12) using an immunocompetent mouse model mimicking the clinical features of mandibular bone invasion. METHODS: The effects of IL-12 on tumor growth and bone resorption were evaluated using subcutaneous and bone invasion models of OSCC in both immunocompetent and athymic mice. Bone resorption was assessed by micro-computed tomography (CT). In addition, quantitative polymerase chain reaction (qPCR) was performed to quantify the expression of osteoclast markers (Acp5, Ctsk) and immune-related genes (Ifng, Fasl). RESULTS: Intratumoral injection of recombinant murine IL-12 (r-mIL-12) significantly prolonged mouse survival and suppressed tumor growth in immunocompetent mice. Micro-CT revealed reduced bone resorption in the r-mIL-12-treated group. Consistently, qPCR demonstrated downregulation of Acp5 and Ctsk, along with upregulation of Ifng and Fasl compared to controls. In contrast, r-mIL-12 treatment had no significant effect on tumor growth or bone resorption in athymic mice, underscoring the importance of T cells in controlling bone invasion. CONCLUSIONS: These findings suggest that local administration of r-mIL-12 may serve as an effective therapeutic approach for OSCC with mandibular bone invasion.
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@article{Kasahara2026Intratumoral,
title = {Intratumoral Administration of Recombinant Murine Interleukin‐12 Prevents Tumor Progression and Bone Invasion},
author = {Shun Kasahara and Miki Kashiwagi and Toshihiro Inubushi and Akinari Sugauchi and Wu Deyong and Kyoko Kurioka and Kazuaki Miyagawa and Takuma Matsuda and S Seki and Mikihiko Kogo and Susumu Tanaka and Toshihiro Uchihashi},
journal = {Oral Diseases},
year = {2026},
doi = {10.1111/odi.70399},
url = {https://doi.org/10.1111/odi.70399}
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