Cancer Genomics and Diagnostics Open access Peer reviewed

Technology and Future of Multi-Cancer Early Detection

Jochen K. Lennerz, Danny A. Milner

Life | Jun 29, 2024 | 36 citations

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The potential of multi-omics approaches, which integrate genomic, transcriptomic, proteomic, and metabolomic data, to enhance early cancer detection are explored.

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Cancer remains a significant global health challenge due to its high morbidity and mortality rates. Early detection is essential for improving patient outcomes, yet current diagnostic methods lack the sensitivity and specificity needed for identifying early-stage cancers. Here, we explore the potential of multi-omics approaches, which integrate genomic, transcriptomic, proteomic, and metabolomic data, to enhance early cancer detection. We highlight the challenges and benefits of data integration from these diverse sources and discuss successful examples of multi-omics applications in other fields. By leveraging these advanced technologies, multi-omics can significantly improve the sensitivity and specificity of early cancer diagnostics, leading to better patient outcomes and more personalized cancer care. We underscore the transformative potential of multi-omics approaches in revolutionizing early cancer detection and the need for continued research and clinical integration.

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Authors

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Jochen K. Lennerz

last | Addgene | ORCID 0000-0003-2434-4978

Danny A. Milner

first | Union for International Cancer Control | ORCID 0000-0002-6685-8208

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BibTeX

@article{Lennerz2024Technology,
  title = {Technology and Future of Multi-Cancer Early Detection},
  author = {Jochen K. Lennerz and Danny A. Milner},
  journal = {Life},
  year = {2024},
  doi = {10.3390/life14070833},
  url = {https://doi.org/10.3390/life14070833}
}

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