Aquaculture disease management and microbiota
Open access
Peer reviewed
Abstract
Abstract
Although major histocompatibility complex (MHC) genes are the most polymorphic genes in vertebrates, we still lack a clear understanding about the extent of polymorphism and selection mechanisms dominantly driving it. Here, we use 29 haploid genome assemblies resolved by long-read sequencing to characterize MHC II genes in Atlantic herring, a pelagic fish and one of the most abundant vertebrates on Earth. We found nine MHC II loci in total distributed on four chromosomes, three of which were extremely polymorphic because of high sequence diversity, in particular at peptide binding sites, along with high copy number variation. This study reveals that the herring MHC class II genes are among the most, if not the most, polymorphic so far described in vertebrates.
Direct answer
What can I do from this paper page?
Use this page to scan "Unheralded high MHC class II polymorphism in the abundant Atlantic herring resolved by long-read sequencing" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Aquaculture disease management and microbiota research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Jamsandekar2026Unheralded,
title = {Unheralded high MHC class II polymorphism in the abundant Atlantic herring resolved by long-read sequencing},
author = {Minal Jamsandekar and Fahime Mohamadnejad Sangdehi and Florian Berg and Michael F. Criscitiello and Brian W. Davis and Mårten Larsson and Jingyi Li and Mats E. Pettersson and Leif Andersson},
journal = {Science Advances},
year = {2026},
doi = {10.1126/sciadv.aea2862},
url = {https://doi.org/10.1126/sciadv.aea2862}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Aquaculture disease management and microbiota research papers?
Follow Aquaculture disease management and microbiota research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Unheralded high MHC class II polymorphism in the abundant Atlantic herring resolved by long-read sequencing. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app