Renin-Angiotensin System Studies Open access Peer reviewed

Extracellular vesicles from the rostral ventrolateral medulla microenvironment regulate stress-induced hypertension via TNF-α-mediated modulation of neuronal excitability

Haisheng Liu, Xiaole Chang, Linping Wang, Wen Lu and 3 more

Clinical and Experimental Hypertension | Sep 3, 2026

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What this paper is about

RVLM-derived EVs promote SIH by delivering TNF-α, which enhances RVLM pre-sympathetic neuronal excitability and sympathetic overactivity, and TNF-α in RVLM-EVs is a promising therapeutic target for SIH.

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OBJECTIVE: Stress-induced hypertension (SIH) is driven by sympathetic overactivity, with the rostral ventrolateral medulla (RVLM) serving as a key regulatory hub. Extracellular vesicles (EVs) mediate intercellular communication, but their role in RVLM-related SIH pathogenesis remains unclear. METHODS: antagonist R7050 was administered for both in vitro and in vivo interventions to examine its regulatory effects on neuronal excitability and blood pressure. RESULTS: was enriched in SIH-RVLM-EVs; R7050 abrogated these pro-hypertensive effects in vitro and in vivo. CONCLUSION: in RVLM-EVs is a promising therapeutic target for SIH.

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Authors

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Haisheng Liu

first | Heze University | ORCID 0000-0002-7815-7409

Xiaole Chang

middle | Shanghai University

Linping Wang

middle | Shanghai University

Wen Lu

middle | Heze University

Chen Yu

middle | Jiangsu Cancer Hospital

Dongshu Du

middle | Shanghai University | ORCID 0000-0003-1198-1089

Wei Guo

last | Heze University

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Latest Cardiovascular, Neuropeptides, and Oxidative Stress Research Latest Renin-Angiotensin System Studies research Latest Nitric Oxide and Endothelin Effects research

Citation

BibTeX

@article{Liu2026Extracellular,
  title = {Extracellular vesicles from the rostral ventrolateral medulla microenvironment regulate stress-induced hypertension via TNF-α-mediated modulation of neuronal excitability},
  author = {Haisheng Liu and Xiaole Chang and Linping Wang and Wen Lu and Chen Yu and Dongshu Du and Wei Guo},
  journal = {Clinical and Experimental Hypertension},
  year = {2026},
  doi = {10.1080/10641963.2026.2726549},
  url = {https://doi.org/10.1080/10641963.2026.2726549}
}

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