Metastasis and carcinoma case studies
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A patient with gastric cancer who developed intestinal pseudo-obstruction and multisystem immune toxicity during postoperative adjuvant chemotherapy plus nivolumab is reported, and the patient’s symptoms improved rapidly after glucocorticoid treatment.
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Background Immune checkpoint inhibitors are increasingly recognized to be associated with multisystem immune-related adverse events. Cases presenting predominantly with intestinal pseudo-obstruction (IPO) are rare, prone to misdiagnosis, and may indicate broader immune-mediated toxicity. Case presentation We report the case of a patient with gastric cancer who developed intestinal pseudo-obstruction and multisystem immune toxicity during postoperative adjuvant chemotherapy plus nivolumab. The patient’s symptoms improved rapidly after glucocorticoid treatment. Conclusion Immune checkpoint inhibitor-related intestinal pseudo-obstruction (irIPO) should be recognized early and diagnosed on the basis of a comprehensive clinical assessment. Differential diagnosis, multidisciplinary collaboration, and active screening for additional organ involvement are essential. Early glucocorticoid treatment may improve clinical outcomes.
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@article{Liu2026Immune,
title = {Immune checkpoint inhibitor-related intestinal pseudo-obstruction and multisystem immune-related adverse events in a post-gastrectomy patient: a case report and literature review},
author = {Zhening Liu and Chao Wang and Yulei Shen and Yanfen Shi and Jianghui Duan and Huijing Dong and Yangbo Xu and Yumin Zheng and Huijuan Cui},
journal = {Frontiers in Oncology},
year = {2026},
doi = {10.3389/fonc.2026.1904273},
url = {https://doi.org/10.3389/fonc.2026.1904273}
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