interferon and immune responses
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A comprehensive functional atlas of stimulator of interferon genes (STING) is presented, revealing how distinct structural regions of STING collectively regulate interferon induction, NF-κ B activation and non-canonical autophagy.
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In a recent publication in Nature , Zhang et al. present a comprehensive functional atlas of stimulator of interferon genes (STING), a central adaptor of innate immunity. 1 By systematically interrogating thousands of single amino-acid substitutions, the study reveals how distinct structural regions of STING collectively regulate interferon induction, NF-κB activation and non-canonical autophagy. The work provides a new molecular framework for understanding STING activation, disease-associated variants and future therapeutic modulation of this pathway.
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@article{Cuapio2026Precision,
title = {Precision tuning of STING signaling: a mutational blueprint},
author = {Angélica Cuapio and Hans‐Gustaf Ljunggren},
journal = {Signal Transduction and Targeted Therapy},
year = {2026},
doi = {10.1038/s41392-026-02968-y},
url = {https://doi.org/10.1038/s41392-026-02968-y}
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