Pancreatitis Pathology and Treatment
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Treatment with olezarsen led to a significantly greater reduction in the triglyceride level at 6 months and in the incidence of acute pancreatitis than placebo, and decreases in the levels of triglycerides, apolipoprotein C-III, remnant cholesterol, and non-HDL cholesterol were greater with olezarsen than with placebo.
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Among patients with severe hypertriglyceridemia, treatment with olezarsen led to a significantly greater reduction in the triglyceride level at 6 months and in the incidence of acute pancreatitis than placebo. (Funded by Ionis Pharmaceuticals; CORE-TIMI 72a and CORE2-TIMI 72b ClinicalTrials.gov numbers, NCT05079919 and NCT05552326.).
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@article{Nicholls2025Olezarsen,
title = {Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk},
author = {Stephen J. Nicholls and Sotirios Tsimikas and Robert P. Giugliano and Marc S Sabatine and Børge G. Nordestgaard and Min‐Ji Charng and Nicholas A. Marston and Brian A. Bergmark and Veronica Alexander and Thomas A Prohaska and Yu Mi Kang and Filipe A. Moura and Andre Zimerman and Elaine Waldman and Julia Weinland and Sabina A. Murphy and Erica L. Goodrich and S. M. Zhang and Shuting Xia and Dan Li and Anne C. Goldberg and Assen Goudev and Lina Badimón and Róbert Gábor Kiss and Michal Vrablı́k and Daniel Gaudet and Philippe Moulin and Erik S.G. Stroes and Maciej Banach and Hofit Cohen and Dirk Blom},
journal = {New England Journal of Medicine},
year = {2025},
doi = {10.1056/nejmoa2512761},
url = {https://doi.org/10.1056/nejmoa2512761}
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