Diabetes Treatment and Management
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Current understanding of the direct and indirect antiinflammatory effects and mechanisms of GLP-1 medicines in both preclinical and clinical studies are highlighted, covering emerging concepts, clinical relevance, and areas of uncertainty that require further investigation.
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Therapies based on glucagon-like peptide-1 (GLP-1) reduce rates of cardiovascular and chronic kidney disease in people with type 2 diabetes and/or obesity, with ongoing clinical trials investigating their effects in people with metabolic liver disease, arthritis, and both substance use and neurodegenerative disorders. Acute and chronic activation of GLP-1 receptor signaling also reduces systemic and tissue inflammation in mice and humans, through weight loss-dependent and -independent mechanisms, actions that may contribute to the expanding spectrum of clinical benefits ascribed to GLP-1 medicines. In this Review, we highlight current understanding of the direct and indirect antiinflammatory effects and mechanisms of GLP-1 medicines in both preclinical and clinical studies, covering emerging concepts, clinical relevance, and areas of uncertainty that require further investigation.
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@article{Wong2025Antiinflammatory,
title = {Antiinflammatory actions of glucagon-like peptide-1–based therapies beyond metabolic benefits},
author = {Chi Kin Wong and Daniel J. Drucker},
journal = {Journal of Clinical Investigation},
year = {2025},
doi = {10.1172/jci194751},
url = {https://doi.org/10.1172/jci194751}
}FAQ
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