Antifungal resistance and susceptibility
Open access
Peer reviewed
Scollr summary
What this paper is about
A shift toward nonalbicans Candida, especially C .
Full abstract
Read the full abstract
Abstract Objectives: Candida species have emerged as significant nosocomial pathogens, particularly in intensive care settings, with Candida auris posing an increasingly severe global public health threat due to its multidrug resistance and potential for outbreaks. This study aimed to investigate the species distribution, antifungal resistance patterns, and virulence traits of Candida isolates in bloodstream infections (BSIs), with a focus on C . auris . Materials and Methods: A prospective observational study was conducted over 18 months in the Tertiary Care Teaching Hospital of western Maharashtra, India, involving 127 patients with culture-confirmed candidemia. All isolates were identified using conventional and/or automated systems, with molecular confirmation of C . auris along with several resistance genes detection ( erg11 , fks1 ) via polymerase chain reaction. Antifungal susceptibility testing was performed using VITEK 2 for all Candida isolates. Phenotypic assays for virulence factors were performed to assess biofilm formation. Results: Among all candidemia cases, Candida tropicalis (37.8%) was the most prevalent species, followed by C . auris (18.1%), Candida albicans (15.7%), and Candida glabrata (11%). High rates of fluconazole resistance were noted, particularly in C . auris (100%) and C . glabrata . Echinocandin resistance was not seen, but it is concerning in C . auris . Biofilm formation was detected in most C . auris (98%) isolates. The erg11 gene was detected in all azole-resistant C . auris isolates. Conclusion: This study highlights a shift toward nonalbicans Candida , especially C . auris , in BSIs and underscores the urgent need for early detection, antifungal resistance surveillance, and stringent infection control practices. The integration of molecular diagnostics and stewardship programs is imperative for improving patient outcomes and limiting nosocomial transmission.
Direct answer
What can I do from this paper page?
Use this page to scan "Species Distribution and Resistance Mechanisms of Candida Isolates in Candidemia: Insights into the Rise of Candida auris" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Antifungal resistance and susceptibility research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Patil2026Species,
title = {Species Distribution and Resistance Mechanisms of Candida Isolates in Candidemia: Insights into the Rise of Candida auris},
author = {Rajashri Patil and Sundip Mukherjee and Nageswari Gandham and Chanda Vyawahare and Jyoti Ajagunde and Tejashree Nare and Muhammad Salim Khan and Sahjid Mukhida},
journal = {Journal of Marine Medical Society},
year = {2026},
doi = {10.4103/jmms.jmms_167_25},
url = {https://doi.org/10.4103/jmms.jmms_167_25}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Antifungal resistance and susceptibility research papers?
Follow Antifungal resistance and susceptibility research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Species Distribution and Resistance Mechanisms of Candida Isolates in Candidemia: Insights into the Rise of Candida auris. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app