Peripheral Artery Disease Management
Open access
Peer reviewed
Scollr summary
What this paper is about
Rheocarna may support wound healing and limb salvage in patients with CLTI undergoing hemodialysis; however, its clinical effectiveness appears limited in advanced disease stages.
Full abstract
Read the full abstract
BACKGROUND: Chronic limb-threatening ischemia (CLTI) is a severe form of lower-extremity artery disease characterized by distal lesions and microcirculatory impairment, limiting revascularization efficacy. Rheocarna is a direct hemoperfusion low-density lipoprotein (LDL) adsorption device with potential rheological and anti-inflammatory benefits. The real-world effectiveness of Rheocarna in patients with advanced CLTI undergoing hemodialysis (HD) remains unclear. This study evaluated clinical outcomes of Rheocarna therapy in patients with CLTI undergoing HD. METHODS: We retrospectively reviewed 31 patients undergoing HD (mean [±SD] age 67 ± 11 years) with CLTI treated with Rheocarna at a single center. Primary outcomes were ulcer healing at 6 months and amputation-free survival (AFS) at 1 year, with baseline characteristics compared between healed and non-healed groups. RESULTS: At 6 months, the ulcer healing, major amputation, and mortality rates were 25.8%, 35.5%, and 22.6%, respectively. The 1-year AFS rate was 40%. The mean ankle-brachial index significantly improved from 1.00 ± 0.17 to 1.07 ± 0.15 (p = 0.041). CONCLUSION: Rheocarna may support wound healing and limb salvage in patients with CLTI undergoing HD; however, its clinical effectiveness appears limited in advanced disease stages.
Direct answer
What can I do from this paper page?
Use this page to scan "Effectiveness of a Novel Low‐Density Lipoprotein Apheresis Device Rheocarna in Patients Undergoing Hemodialysis With Chronic Limb‐Threatening Ischemia: A Single‐Center Retrospective Study" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Peripheral Artery Disease Management research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Ishioka2026Effectiveness,
title = {Effectiveness of a Novel Low‐Density Lipoprotein Apheresis Device Rheocarna in Patients Undergoing Hemodialysis With Chronic Limb‐Threatening Ischemia: A Single‐Center Retrospective Study},
author = {Kunihiro Ishioka and Takayasu Ohtake and Kei Ohmori and Chika Shibuya and Tomoki Tsukahara and Mizuki Yamano and Yasuhiro Mochida and Machiko Oka and Kyoko Maesato and Yusuke Tsukamoto and Hidekazu Moriya and Sumi Hidaka and Shuzo Kobayashi},
journal = {Therapeutic Apheresis and Dialysis},
year = {2026},
doi = {10.1002/1744-9987.70164},
url = {https://doi.org/10.1002/1744-9987.70164}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Peripheral Artery Disease Management research papers?
Follow Peripheral Artery Disease Management research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Effectiveness of a Novel Low‐Density Lipoprotein Apheresis Device Rheocarna in Patients Undergoing Hemodialysis With Chronic Limb‐Threatening Ischemia: A Single‐Center Retrospective Study. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app