Cancer-related Molecular Pathways
Open access
Peer reviewed
Scollr summary
What this paper is about
Cyclin D1 serves as a molecular hallmark of differentiation in breast cancer, being robustly maintained in hormone-dependent, lower-grade tumors and lost in aggressive, de-differentiated phenotypes.
Full abstract
Read the full abstract
Background: Breast cancer in India often presents with aggressive characteristics and high mortality. Cyclin D1 is a critical regulator of the G1/S phase transition and is emerging as a significant biomarker.Methods: A cross-sectional study of 52 mastectomy specimens was conducted. Histological grading (Nottingham modification) and immunohistochemical (IHC) staining for ER, PR, Her2Neu, and Cyclin D1 were performed. Result: Cyclin D1 positivity was observed in 51.9% of cases. A highly significant positive correlation was found between Cyclin D1 expression and ER status (p < 0.001) and PR status (p < 0.001). Conversely, Cyclin D1 showed a strong inverse correlation with histological grade (p = 0.002); Grade III tumors were significantly more likely to be Cyclin D1 negative. No significant correlation was found with age, tumor size, or lymph node status.Conclusion: Cyclin D1 serves as a molecular hallmark of differentiation in breast cancer, being robustly maintained in hormone-dependent, lower-grade tumors and lost in aggressive, de-differentiated phenotypes.
Direct answer
What can I do from this paper page?
Use this page to scan "The Evolving Role of Cyclin D1 as a Biological Surrogate for Differentiation and Hormone Receptor Status in Breast Carcinoma" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Cancer-related Molecular Pathways research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Verma2026Evolving,
title = {The Evolving Role of Cyclin D1 as a Biological Surrogate for Differentiation and Hormone Receptor Status in Breast Carcinoma},
author = {Abhishek Verma and Manisha Sharma and Manas Madan and Karamjit S. Gill},
journal = {Annals of Pathology and Laboratory Medicine},
year = {2026},
doi = {10.21276/apalm.3885},
url = {https://doi.org/10.21276/apalm.3885}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Cancer-related Molecular Pathways research papers?
Follow Cancer-related Molecular Pathways research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for The Evolving Role of Cyclin D1 as a Biological Surrogate for Differentiation and Hormone Receptor Status in Breast Carcinoma. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app